UniProt ID: Q1LVK9 |
FUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity). {ECO:0000250|UniProtKB:O75113, ECO:0000250|UniProtKB:Q6A037}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, PML body {ECO:0000250|UniProtKB:Q6A037}. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies. {ECO:0000250|UniProtKB:Q6A037}. SIMILARITY: Belongs to the N4BP1 family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH59205.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
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