UniProt ID: Q6NYV5 |
FUNCTION: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:22821512). Required for normal expression of numerous target genes (PubMed:22821512). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double- stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (By similarity). {ECO:0000250|UniProtKB:Q9HAJ7, ECO:0000269|PubMed:22821512}. SUBUNIT: Interacts with components of the histone deacetylase complex sin3a, hdac1 and hdac2. Binds histones and nucleosomes. {ECO:0000250|UniProtKB:Q9HAJ7}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9HAJ7}. TISSUE SPECIFICITY: Detected in embryos at 2dpf (at protein level). Widely expressed during embryogenesis and in adults. {ECO:0000269|PubMed:22821512}. DOMAIN: The zinc-finger domain mediates direct interaction with DNA and phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate). In vitro oxydation causes reversible disulfide bond formation between Cys residues in the zinc-finger domain and reversible loss of zinc ion binding. {ECO:0000250|UniProtKB:Q9HAJ7}. DISRUPTION PHENOTYPE: Morpholino knockdown causes defects in embryonic heart morphogenesis and pericardiac edema, with defects in heart function that are visible already at 3 dpf. In addition, erythrocytes appear pale due to decreased hemoglobin content. {ECO:0000269|PubMed:22821512}. SIMILARITY: Belongs to the SAP30 family. {ECO:0000305}. |
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