UniProt ID: Q7ZU80 |
FUNCTION: Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000250|UniProtKB:Q9C0E8}. SUBUNIT: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner. {ECO:0000250|UniProtKB:Q6DFJ8}. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9C0E8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9C0E8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9C0E8}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000250|UniProtKB:Q9C0E8}. DOMAIN: The transmembrane domain 1 and 2 function as a signal-anchor and stop-transfer sequence, respectively, generating a double-spanning integral membrane protein with a N- and C-terminal cytoplasmic orientation. Transmembrane domain 1 and 2 are probably sufficient to mediate membrane translocation and topology formation in a N- myristoylation-independent manner. Transmembrane domain 2 is sufficient to block the protein secretion pathway. The two coiled-coil domains are necessary for its endoplasmic reticulum (ER) three-way tubular junction localization. The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. {ECO:0000250|UniProtKB:Q9C0E8}. PTM: Phosphorylated. Phosphorylation occurs during interphase. Phosphorylation occurs also during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation. {ECO:0000250|UniProtKB:Q6DFJ8}. SIMILARITY: Belongs to the lunapark family. {ECO:0000305}. |
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