UniProt ID: Q7ZV90 |
FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. {ECO:0000255|HAMAP-Rule:MF_03176}. CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000255|HAMAP-Rule:MF_03176}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_03176}; SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_03176}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03176}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03176}. SIMILARITY: Belongs to the helicase family. PIF1 subfamily. {ECO:0000255|HAMAP-Rule:MF_03176}. |
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