UniProt ID: Q58A48 |
FUNCTION: Contributes to various developmental events through its interactions with multiple signaling pathways (By similarity). Dorsalizing factor which functions as an inhibitor of bone morphogenetic proteins during gastrulation (PubMed:15363410). {ECO:0000250|UniProtKB:Q65Z91, ECO:0000269|PubMed:15363410}. SUBUNIT: Forms a ternary complex with chordin/CHRD and BMP4. {ECO:0000250|UniProtKB:Q65Z91}. SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q65Z91}. DEVELOPMENTAL STAGE: Expressed in the germ ring including the shield at shield stage and in the tailbud at 10-somite stage. {ECO:0000269|PubMed:15363410}. MISCELLANEOUS: This factor is named 'Tsukushi' because its expression pattern in chick embryos is similar to the shape of the Japanese horsetail plant, tsukushi. {ECO:0000250|UniProtKB:Q65Z91}. |
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