UniProt ID: Q6P3H7 |
FUNCTION: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. {ECO:0000250|UniProtKB:Q09028}. SUBUNIT: Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin (By similarity). {ECO:0000250|UniProtKB:O93377, ECO:0000250|UniProtKB:Q09028}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09028}. Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}. SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. {ECO:0000305}. |
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