UniProt ID: B0S6R1
FUNCTION: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). {ECO:0000250}.
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.
SIMILARITY: Belongs to the HEM-1/HEM-2 family. {ECO:0000305}.
SEQUENCE CAUTION: Sequence=CAQ13346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ14913.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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