UniProt ID: A3KPA0 |
FUNCTION: Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes (PubMed:22180726). {ECO:0000250|UniProtKB:P57087, ECO:0000269|PubMed:22180726}. INTERACTION: A3KPA0; A4JYM3: jam2a; NbExp=5; IntAct=EBI-1579361, EBI-1579304; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BX67}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX67}. Cell junction {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9BX67}. DEVELOPMENTAL STAGE: Expressed in the somites of the embryo in a wave along the anterior-posterior axis. {ECO:0000269|PubMed:22180726}. DISRUPTION PHENOTYPE: Morpholino knockdown impairs myocyte fusion during myogenesis. {ECO:0000269|PubMed:22180726}. SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}. |
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