UniProt ID: A0A8M3AQ52 |
FUNCTION: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. {ECO:0000256|HAMAP-Rule:MF_03062}. CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|HAMAP-Rule:MF_03062, ECO:0000256|RuleBase:RU366025}; SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_03062}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03062}. DOMAIN: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. {ECO:0000256|HAMAP-Rule:MF_03062}. SIMILARITY: Belongs to the peptidase C19 family. USP16 subfamily. {ECO:0000256|HAMAP-Rule:MF_03062}. |
UniProt ID: A0A8M9QHB9 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025}; SIMILARITY: Belongs to the peptidase C19 family. {ECO:0000256|RuleBase:RU366025}. |
UniProt ID: A0A8M9QC36 |
FUNCTION: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. {ECO:0000256|HAMAP-Rule:MF_03062}. CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|HAMAP-Rule:MF_03062, ECO:0000256|RuleBase:RU366025}; SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_03062}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03062}. DOMAIN: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. {ECO:0000256|HAMAP-Rule:MF_03062}. SIMILARITY: Belongs to the peptidase C19 family. USP16 subfamily. {ECO:0000256|HAMAP-Rule:MF_03062}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |