UniProt ID: A0A2R8QR48 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the THOC5 family. {ECO:0000256|ARBA:ARBA00008044}. |
UniProt ID: Q6NY52 |
FUNCTION: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). {ECO:0000250}. FUNCTION: May be involved in cell differentiation. {ECO:0000250}. SUBUNIT: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP- dependent remodeling. {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. SIMILARITY: Belongs to the THOC5 family. {ECO:0000305}. |
UniProt ID: F1RB69 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the THOC5 family. {ECO:0000256|ARBA:ARBA00008044}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |