UniProt ID: Q6NV31 |
FUNCTION: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C- terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs). {ECO:0000250|UniProtKB:Q6UXN9}. SUBUNIT: Component of the SET1 complex. {ECO:0000250|UniProtKB:Q6UXN9}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UXN9}. Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with chromatin (By similarity). Recruited at sites of high RNA polymerase II occupancy (By similarity). {ECO:0000250|UniProtKB:Q6UXN9, ECO:0000250|UniProtKB:Q8BFQ4}. SIMILARITY: Belongs to the WD repeat SWD2 family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |