UniProt ID: F1QB54 |
FUNCTION: Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Binds to N6-methyladenosine (m6A)-containing mRNAs (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation (PubMed:31399345). {ECO:0000250|UniProtKB:P11940, ECO:0000250|UniProtKB:P20965, ECO:0000269|PubMed:31399345}. SUBUNIT: Interacts with ybx1; interaction recruits pabpc1a on C5- methylcytosine (m5C)-containing mRNAs, preventing their degradation. {ECO:0000269|PubMed:31399345}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P20965}. Note=Associated with polysomes. {ECO:0000250|UniProtKB:P20965}. DOMAIN: RRM4, together with the C- and N-terminal regions, is sufficient for RNA-binding. RRM 1 has no RNA-binding activity itself, but improves discrimination between poly(A) and poly(U) in combination with the other repeats. {ECO:0000250|UniProtKB:P20965}. SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family. {ECO:0000255|RuleBase:RU362004}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |