UniProt ID: Q58EL7
FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q8IX90}.
SUBUNIT: Component of the SKA1 complex, composed of ska1, ska2 and ska3. {ECO:0000250}.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8IX90}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8IX90}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000250|UniProtKB:Q8IX90}.
SIMILARITY: Belongs to the SKA3 family. {ECO:0000305}.
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