UniProt ID: Q6EIG3
FUNCTION: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development. {ECO:0000269|PubMed:15661642, ECO:0000269|PubMed:22019272}.
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
DEVELOPMENTAL STAGE: Expressed zygotically. Weak expression at 75% epiboly. At the 2-somite stage, expressed in the presumptive rhombomere 4 (r4) region partially overlapping with the r3 region. At the 10-somite stage, expressed in the r4, r3 and r2 regions. At the 14-somite stage, expression extends to the r5 and r6 regions and is observed in the diencephalon. At 24-48 hours post- fertilization (hpf), additionally expressed in the eye, midbrain- hindbrain boundary, cerebellum, pectoral fin and the pharyngeal arch primordia. {ECO:0000269|PubMed:15661642}.
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000255}.
UniProt ID: A0A0R4I9F4
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461, ECO:0000256|SAAS:SAAS00578476}.
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