UniProt ID: A0A8M2BID5 |
FUNCTION: Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173). {ECO:0000269|PubMed:29522173}. SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000250|UniProtKB:E9Q557}. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. DEVELOPMENTAL STAGE: Expressed in the periderm and enveloping layer between 6 hours post-fertilization (hpf) to 16 hpf. Expressed in the epidermis, otic vesicle, gut, neural tube, pharynx, pectoral fin, and olfactory organ from 1 to 5 dpf. Expressed in the lens and cardiac region at 6 hpf to 5 dpf. {ECO:0000269|PubMed:29522173}. DISRUPTION PHENOTYPE: Morpholino knockdowns show no general morphological differences however do show a slight developmental delay (PubMed:29522173). Abnormal skin surface, reduced numbers of desmosome cell-cell junctions and disorganization of remaining desmosome at 2 dpf (PubMed:29522173). Cardiac regions show reduced desmosome numbers, detached cells and pericardial effusion. Reduced resting heart rate (PubMed:29522173). A cardiac reduction in Wnt and TGF-beta signaling is also evident, with an increase in Hippo signaling (PubMed:29522173). {ECO:0000269|PubMed:29522173}. SIMILARITY: Belongs to the plakin or cytolinker family. {ECO:0000305}. |
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