UniProt ID: Q6P3H0 |
FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE- containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. {ECO:0000256|RuleBase:RU369014}. SUBUNIT: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes. {ECO:0000256|RuleBase:RU369014}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369014}. Cytoplasm {ECO:0000256|RuleBase:RU369014}. |
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