UniProt ID: Q802Y8
FUNCTION: Probable transcription factor. Probable substrate- recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis. {ECO:0000250|UniProtKB:Q05516, ECO:0000269|PubMed:20080956}.
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q05516}.
SUBUNIT: Interacts with btbd6a (via BTB domain). {ECO:0000269|PubMed:20080956}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20080956}. Cytoplasm {ECO:0000269|PubMed:20080956}. Note=Nuclear export to the cytoplasm is promoted by btbd6a. {ECO:0000269|PubMed:20080956}.
TISSUE SPECIFICITY: During early stages of primary neurogenesis, expressed in the neural epithelium, with highest levels in the forebrain and midbrain. Also expressed in a posterior-to-anterior gradient in the caudal neural plate at the 3-6 somite stage. {ECO:0000269|PubMed:20080956}.
PTM: Polyubiquitinated, leading to its proteasomal degradation. {ECO:0000269|PubMed:20080956}.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000255}.
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