UniProt ID: A4QNY6
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO:0000256|RuleBase:RU363081}.
CATALYTIC ACTIVITY: Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence={ECO:0000256|RuleBase:RU363081};
SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family. {ECO:0000256|RuleBase:RU363081}.
UniProt ID: Q5SPB6
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3- DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. {ECO:0000250|UniProtKB:Q9BUX1}.
CATALYTIC ACTIVITY: Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence={ECO:0000250|UniProtKB:Q9BUX1};
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BUX1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.
SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. {ECO:0000305}.
UniProt ID: A8KBI9
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO:0000256|RuleBase:RU363081}.
CATALYTIC ACTIVITY: Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence={ECO:0000256|RuleBase:RU363081};
SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family. {ECO:0000256|RuleBase:RU363081}.
UniProt ID: A8KBI8
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO:0000256|RuleBase:RU363081}.
CATALYTIC ACTIVITY: Reaction=glutathione = 5-oxo-L-proline + L-cysteinylglycine; Xref=Rhea:RHEA:47724, ChEBI:CHEBI:57925, ChEBI:CHEBI:58402, ChEBI:CHEBI:61694; EC=4.3.2.7; Evidence={ECO:0000256|RuleBase:RU363081};
SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family. {ECO:0000256|RuleBase:RU363081}.
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