UniProt ID: Q7ZWK8 |
FUNCTION: Proton-selective channel that specifically transports protons into cells (By similarity). Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (By similarity). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (PubMed:15480759, PubMed:15581873). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). {ECO:0000250|UniProtKB:Q80VM9, ECO:0000269|PubMed:15480759, ECO:0000269|PubMed:15581873}. INTERACTION: Q7ZWK8; Q7ZWK8: otop1; NbExp=2; IntAct=EBI-22085919, EBI-22085919; SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15480759}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium. {ECO:0000250|UniProtKB:Q80VM9}. DEVELOPMENTAL STAGE: First detected in the otic placode at 16.5 hours post-fertilization (hpf). Detected in the developing inner ear sensory epithelium at 24 hpf. Detected in hair cells of the sensory epithelium at 4 days post-fertilization (dpf). At 5 dpf, levels are much reduced in the otolith organs, and not detectable at 7 dpf. Detected in neuromasts and in the lateral line system at 5 dpf and 7 dpf. {ECO:0000269|PubMed:15480759, ECO:0000269|PubMed:15581873}. DISRUPTION PHENOTYPE: Fishes display the backstroke phenotype. Mutant fish exhibit otolith agenesis without additional effects on the sensory epithelium or other inner ear structures. Otoliths are essential for the perception of gravity and acceleration. Larvae without otoliths are unable to orient dorsal side up and rest mostly on their side in contact with the ground. {ECO:0000269|PubMed:15480759, ECO:0000269|PubMed:15581873, ECO:0000269|PubMed:9007244}. SIMILARITY: Belongs to the otopetrin family. {ECO:0000305}. WEB RESOURCE: Name=Protein Spotlight; Note=Ear of stone - Issue 89 of December 2007; URL="https://web.expasy.org/spotlight/back_issues/089"; |
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