UniProt ID: Q6NWL4
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
SUBUNIT: Homodimer. Component of the CCR4-NOT complex (By similarity). {ECO:0000250}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}.
SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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