UniProt ID: Q6PEI6 |
FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. {ECO:0000256|ARBA:ARBA00003113}. CATALYTIC ACTIVITY: Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336, ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00023501, ECO:0000256|RuleBase:RU362107}; COFACTOR: Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000256|RuleBase:RU362107}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000256|RuleBase:RU362107}; PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. {ECO:0000256|ARBA:ARBA00004717}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU362107}. SIMILARITY: Belongs to the aconitase/IPM isomerase family. {ECO:0000256|ARBA:ARBA00007185, ECO:0000256|RuleBase:RU362107}. |
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