UniProt ID: A7MBU6 |
FUNCTION: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020}. CATALYTIC ACTIVITY: Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11; Evidence={ECO:0000255|HAMAP- Rule:MF_03020}; COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000255|HAMAP-Rule:MF_03020}; Note=Binds 1 heme group per subunit. {ECO:0000255|HAMAP-Rule:MF_03020}; PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. SUBUNIT: Homotetramer. Dimer of dimers. {ECO:0000255|HAMAP- Rule:MF_03020}. SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family. {ECO:0000255|HAMAP-Rule:MF_03020}. |
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