UniProt ID: A5PF61 |
FUNCTION: Important for early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1b function. {ECO:0000269|PubMed:21857963}. SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21857963}. TISSUE SPECIFICITY: Detected in all tissues tested, with the highest levels in serum (at protein level). At mRNA level, only expressed in liver. {ECO:0000269|PubMed:21857963}. DEVELOPMENTAL STAGE: Expressed as early as 24 hours post fecondation (hpf), expressed at higher levels than leg1b. {ECO:0000269|PubMed:21857963}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes a small liver phenotype. Morpholino which can simultaneously block the translation of leg1a and leg1b, causes a more severe small liver phenotype with hypoplastic exocrine pancreas and intestinal tube as well. {ECO:0000269|PubMed:21857963}. SIMILARITY: Belongs to the LEG1 family. {ECO:0000305}. |
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