UniProt ID: P83571
FUNCTION: Has double-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription. Represses gene activation mediated by beta-catenin. {ECO:0000250|UniProtKB:Q9Y230, ECO:0000269|PubMed:12464178}.
FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250}.
FUNCTION: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. {ECO:0000250|UniProtKB:Q9Y230}.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBUNIT: Forms homohexameric rings (Probable). Can form a dodecamer with ruvbl1 made of two stacked hexameric rings. Component of the chromatin-remodeling Ino80 complex. Component of some MLL1/MLL complex (By similarity). {ECO:0000250, ECO:0000305}.
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
DEVELOPMENTAL STAGE: Widely expressed in the embryo. After 60 hours post-fertilization there is increased expression in heart, liver, branchial arches, exocrine pancreas and intestine. {ECO:0000269|PubMed:12464178}.
DISRUPTION PHENOTYPE: Fishes display embryonic cardiac hyperplasia with increased cell number and size by 72 hours post- fertilization. Gut and gut-derived organs are incapable of growth and differentiation after this time. The mutation enhances ATPase activity, rendering it DNA-independent and causes aggregation of the protein into large complexes. {ECO:0000269|PubMed:12464178}.
SIMILARITY: Belongs to the RuvB family. {ECO:0000250|UniProtKB:Q9Y230}.
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