UniProt ID: B0V1P1 |
FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:23869017}. SUBUNIT: Homodimer; disulfide-linked, also forms higher order oligomers (By similarity). Interacts with mrap2a; decreasing ligand-sensitivity. Interacts with mrap2b; increasing ligand-sensitivity and generation of cAMP. {ECO:0000250, ECO:0000269|PubMed:23869017}. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
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