UniProt ID: B3DKN3 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000256|ARBA:ARBA00008565}. |
UniProt ID: Q8JGR7 |
FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase (By similarity). Essential during embryogenesis for eye development. {ECO:0000250|UniProtKB:Q9NVH2, ECO:0000269|PubMed:12006978, ECO:0000269|PubMed:15716491}. SUBUNIT: Belongs to the multiprotein complex Integrator. {ECO:0000250|UniProtKB:Q9NVH2}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}. Chromosome {ECO:0000250|UniProtKB:Q9NVH2}. DISRUPTION PHENOTYPE: Fishes have a defective lens structure and abnormally shaped jaw and neurocranium. {ECO:0000269|PubMed:12006978, ECO:0000269|PubMed:15716491}. SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000305}. |
UniProt ID: A0A8M9PBK1 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000256|ARBA:ARBA00008565}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |