UniProt ID: Q8JHF4
FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina (PubMed:11992120). {ECO:0000250|UniProtKB:Q8N3R9, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:11992120}.
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11992120}; Peripheral membrane protein {ECO:0000269|PubMed:11992120}. Cell junction, tight junction {ECO:0000269|PubMed:11992120}. Note=Localizes to the apical region of the cell membrane, in the vicinity of junctional complexes in the neuroepithelium and the photoreceptor layer. Enriched in the areas immediately apical to the adherens junctions-associated actin bundles.
TISSUE SPECIFICITY: Expressed in the retina and in the neural tube. {ECO:0000269|PubMed:11992120}.
DEVELOPMENTAL STAGE: Expressed early in development. {ECO:0000269|PubMed:11992120}.
DOMAIN: The PDZ domain is required for apical location. {ECO:0000269|PubMed:11992120}.
SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
SEQUENCE CAUTION: Sequence=AAM77880.1; Type=Erroneous initiation; Evidence={ECO:0000305};
UniProt ID: Q1LVF4
SIMILARITY: Belongs to the MAGUK family. {ECO:0000256|SAAS:SAAS00914726}.
UniProt ID: B3DIW9
SIMILARITY: Belongs to the MAGUK family. {ECO:0000256|SAAS:SAAS00914726}.
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