UniProt ID: Q8UVJ6 |
FUNCTION: Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural progenitor cell morphogenesis, segregation of somites and adaxial cell development. Together with prickle1, required for the posterior (caudal) movement of branchiomotor neurons in the hindbrain independently of, and a few hours after, convergent extension (PubMed:11780127, Ref.2, PubMed:9007230, PubMed:9007234, PubMed:9007236, PubMed:9808788, PubMed:10996075, PubMed:10992326, PubMed:11820812, PubMed:12105418, PubMed:12874125, PubMed:15829519, PubMed:16407953, PubMed:17239849). May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4, ECO:0000269|PubMed:10992326, ECO:0000269|PubMed:10996075, ECO:0000269|PubMed:11780127, ECO:0000269|PubMed:11820812, ECO:0000269|PubMed:12105418, ECO:0000269|PubMed:12874125, ECO:0000269|PubMed:15829519, ECO:0000269|PubMed:16407953, ECO:0000269|PubMed:17239849, ECO:0000269|PubMed:9007230, ECO:0000269|PubMed:9007234, ECO:0000269|PubMed:9007236, ECO:0000269|PubMed:9808788, ECO:0000269|Ref.2}. SUBUNIT: Interacts with the PDZ domain of dvl2/dsh. {ECO:0000269|PubMed:11780127}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. TISSUE SPECIFICITY: Ubiquitously expressed at the 4-cell stage. In early somitogenesis, becomes more abundant in anterior neural tissue where expression is seen in the neural tube but not in the notochord. {ECO:0000269|PubMed:11780127}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, with expression peaking at the neurula stage. {ECO:0000269|PubMed:11780127}. SIMILARITY: Belongs to the Vang family. {ECO:0000255}. SEQUENCE CAUTION: Sequence=AAH65983.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown at the C-terminus, most likely because of a sequence artifact.; Evidence={ECO:0000305}; |
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