UniProt ID: A0A0A0VDB5 |
FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000256|ARBA:ARBA00002566, ECO:0000256|RuleBase:RU362117}. COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|RuleBase:RU362117}; Note=Binds 2 heme groups non-covalently. {ECO:0000256|RuleBase:RU362117}; COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000256|PIRSR:PIRSR038885-2}; Note=Binds 2 heme groups non-covalently. {ECO:0000256|PIRSR:PIRSR038885-2}; SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004448}. SIMILARITY: Belongs to the cytochrome b family. {ECO:0000256|RuleBase:RU362117}. |
UniProt ID: Q9MIX8 |
FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000250|UniProtKB:P00157}. COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250|UniProtKB:P00157}; Note=Binds 2 heme b groups non-covalently. {ECO:0000250|UniProtKB:P00157}; SUBUNIT: The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins. {ECO:0000250|UniProtKB:P00157}. SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00157}. MISCELLANEOUS: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO:0000250}. SIMILARITY: Belongs to the cytochrome b family. {ECO:0000255|PROSITE- ProRule:PRU00967, ECO:0000255|PROSITE-ProRule:PRU00968}. CAUTION: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. {ECO:0000250|UniProtKB:P00157}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |