UniProt ID: Q7T2F0 |
CATALYTIC ACTIVITY: Reaction=glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA; Xref=Rhea:RHEA:12921, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292, ChEBI:CHEBI:57305, ChEBI:CHEBI:356416; EC=2.3.1.37; Evidence={ECO:0000256|ARBA:ARBA00033616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12922; Evidence={ECO:0000256|ARBA:ARBA00033616}; COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000256|ARBA:ARBA00001933, ECO:0000256|RuleBase:RU003693}; PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. {ECO:0000256|ARBA:ARBA00005029, ECO:0000256|RuleBase:RU910713}. SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU910713}; Peripheral membrane protein {ECO:0000256|RuleBase:RU910713}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000256|RuleBase:RU910713}. SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000256|ARBA:ARBA00008392, ECO:0000256|RuleBase:RU003693}. |
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