UniProt ID: Q9DDT5 |
FUNCTION: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. {ECO:0000269|PubMed:11099044, ECO:0000269|PubMed:11923199}. SUBUNIT: Interacts with SUPT4H1 to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11099044}. DEVELOPMENTAL STAGE: Maternally expressed throughout the early blastoderm. Expressed in the neural plate of the tailbud stage embryo, at 10 hours post-fertilization (hpf). Highly expressed in the developing brain at 28 hpf, and at lower levels in the rest of the embryo. {ECO:0000269|PubMed:11099044, ECO:0000269|PubMed:11923199}. PTM: Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing (By similarity). {ECO:0000250}. SIMILARITY: Belongs to the SPT5 family. {ECO:0000305}. |
UniProt ID: A0A8M9Q0J3 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036945}. SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956, ECO:0000256|PIRNR:PIRNR036945}. |
UniProt ID: A0A8M1P6F8 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR036945}. SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956, ECO:0000256|PIRNR:PIRNR036945}. |
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