UniProt ID: Q9DG10 |
FUNCTION: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). {ECO:0000250|UniProtKB:P49675}. CATALYTIC ACTIVITY: Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747, ChEBI:CHEBI:16113; Evidence={ECO:0000250|UniProtKB:P49675}; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000250|UniProtKB:P49675}. SUBUNIT: May interact with TSPO. {ECO:0000250|UniProtKB:P79245}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}. TISSUE SPECIFICITY: Highly expressed in the testis and at lower levels in the ovary, kidney and head. |
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