UniProt ID: Q8AXB3 |
FUNCTION: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. {ECO:0000269|PubMed:12194822, ECO:0000269|PubMed:16617120, ECO:0000269|PubMed:17698971}. CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:16617120}; SUBUNIT: Interacts with isoform VEGF165 of vegfaa and isoform VEGF171 of vegfab. {ECO:0000269|PubMed:17698971}. INTERACTION: Q8AXB3; A4JYN2: bcan; NbExp=2; IntAct=EBI-2267980, EBI-2268253; Q8AXB3; Q8UVD6: boc; NbExp=2; IntAct=EBI-2267980, EBI-2268159; Q8AXB3; A8BBB9: epyc; NbExp=2; IntAct=EBI-2267980, EBI-2268109; Q8AXB3; A4JYI8: fgfr2; NbExp=2; IntAct=EBI-2267980, EBI-2268196; Q8AXB3; A4JYQ2: fgfr3; NbExp=2; IntAct=EBI-2267980, EBI-2268403; Q8AXB3; Q6NW92: igfbp7; NbExp=2; IntAct=EBI-2267980, EBI-1579483; Q8AXB3; Q6NZ26: igsf8; NbExp=2; IntAct=EBI-2267980, EBI-2268334; Q8AXB3; A8BBG3: lrrtm1; NbExp=2; IntAct=EBI-2267980, EBI-2263357; Q8AXB3; A8BB40: lrrtm4l1; NbExp=2; IntAct=EBI-2267980, EBI-2263384; Q8AXB3; A8BBE6: optc; NbExp=2; IntAct=EBI-2267980, EBI-2268084; Q8AXB3; Q6P5M1: pdgfrl; NbExp=2; IntAct=EBI-2267980, EBI-2268346; Q8AXB3; Q90Z69: robo3; NbExp=4; IntAct=EBI-2267980, EBI-2267985; Q8AXB3; A4JYE7: vstm4b; NbExp=2; IntAct=EBI-2267980, EBI-2268137; SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. TISSUE SPECIFICITY: First expressed in embryos between 5- and 7- somites. At 7 somites, expressed in discrete bilateral stripes both anteriorly and posteriorly, and in a transverse ectodermal stripe in the hindbrain. From 7-somites, expression seems to extend caudally from the head, and in both directions in the trunk region, until by 20- somites, expression is detected as a continuous band from the anterior head region to the tailbud. Concurrently, cells expressing kdrl in the mid- and posterior trunk regions converge medially. By 24 hours post- fertilization (hpf), expressed in all the endothelial cells lining the vasculature. {ECO:0000269|PubMed:17698971, ECO:0000269|PubMed:17722983, ECO:0000269|PubMed:9053314, ECO:0000269|PubMed:9119113, ECO:0000269|PubMed:9178253}. PTM: Phosphorylated and activated by vegfaa and vegfab. {ECO:0000269|PubMed:17698971}. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}. CAUTION: Was originally thought to be an ortholog of KDR, but PubMed:18516225 has shown that it represents a fourth vertebrate vascular endothelial growth factor receptor (VEGFR) that is not present in eutherian mammals (marsupials and placental mammals). {ECO:0000305}. |
UniProt ID: A0A8M3AGQ5 |
CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171}; SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000256|RuleBase:RU000311}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |