UniProt ID: A0A0R4IIR3
CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; Evidence={ECO:0000256|RuleBase:RU000311, ECO:0000256|SAAS:SAAS01225995};
SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU000311}.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000256|RuleBase:RU000311}.
UniProt ID: Q8AXB3
FUNCTION: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. {ECO:0000269|PubMed:12194822, ECO:0000269|PubMed:16617120, ECO:0000269|PubMed:17698971}.
CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L- tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:16617120};
SUBUNIT: Interacts with isoform VEGF165 of vegfaa and isoform VEGF171 of vegfab. {ECO:0000269|PubMed:17698971}.
INTERACTION: A4JYN2:bcan; NbExp=2; IntAct=EBI-2267980, EBI-2268253; Q8UVD6:boc; NbExp=2; IntAct=EBI-2267980, EBI-2268159; A8BBB9:epyc; NbExp=2; IntAct=EBI-2267980, EBI-2268109; A4JYI8:fgfr2; NbExp=2; IntAct=EBI-2267980, EBI-2268196; A4JYQ2:fgfr3; NbExp=2; IntAct=EBI-2267980, EBI-2268403; Q6NW92:igfbp7; NbExp=2; IntAct=EBI-2267980, EBI-1579483; Q6NZ26:igsf8; NbExp=2; IntAct=EBI-2267980, EBI-2268334; A8BBG3:lrrtm1; NbExp=2; IntAct=EBI-2267980, EBI-2263357; A8BB40:lrrtm4l1; NbExp=2; IntAct=EBI-2267980, EBI-2263384; A8BBE6:optc; NbExp=2; IntAct=EBI-2267980, EBI-2268084; Q6P5M1:pdgfrl; NbExp=2; IntAct=EBI-2267980, EBI-2268346; Q90Z69:robo3; NbExp=4; IntAct=EBI-2267980, EBI-2267985; A4JYE7:vstm4b; NbExp=2; IntAct=EBI-2267980, EBI-2268137;
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
TISSUE SPECIFICITY: First expressed in embryos between 5- and 7- somites. At 7 somites, expressed in discrete bilateral stripes both anteriorly and posteriorly, and in a transverse ectodermal stripe in the hindbrain. From 7-somites, expression seems to extend caudally from the head, and in both directions in the trunk region, until by 20-somites, expression is detected as a continuous band from the anterior head region to the tailbud. Concurrently, cells expressing kdrl in the mid- and posterior trunk regions converge medially. By 24 hours post-fertilization (hpf), expressed in all the endothelial cells lining the vasculature. {ECO:0000269|PubMed:17698971, ECO:0000269|PubMed:17722983, ECO:0000269|PubMed:9053314, ECO:0000269|PubMed:9119113, ECO:0000269|PubMed:9178253}.
PTM: Phosphorylated and activated by vegfaa and vegfab. {ECO:0000269|PubMed:17698971}.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CAUTION: Was originally thought to be an ortholog of KDR, but PubMed:18516225 has shown that it represents a fourth vertebrate vascular endothelial growth factor receptor (VEGFR) that is not present in eutherian mammals (marsupials and placental mammals). {ECO:0000305}.
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