UniProt ID: A0A8M3AY92 |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. |
UniProt ID: P57094 |
FUNCTION: Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:17681137). Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:17681137, PubMed:30467143). {ECO:0000269|PubMed:17681137, ECO:0000269|PubMed:30467143}. SUBUNIT: Homodimer (By similarity). Interacts with dixdc1 (PubMed:12526749). Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (PubMed:30467143). {ECO:0000250|UniProtKB:O35625, ECO:0000269|PubMed:12526749, ECO:0000269|PubMed:30467143}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15169}. Nucleus {ECO:0000250|UniProtKB:O15169}. Membrane {ECO:0000250|UniProtKB:O35625}. Cell membrane {ECO:0000250|UniProtKB:O35625}. DOMAIN: The DIX domain mediates interaction with dixdc1. {ECO:0000269|PubMed:12526749}. PTM: ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway. {ECO:0000305|PubMed:30467143}. PTM: Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. {ECO:0000305|PubMed:30467143}. |
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