UniProt ID: A0A0R4IYT0 |
SIMILARITY: Belongs to the RRM IMP/VICKZ family. {ECO:0000256|ARBA:ARBA00009094}. |
UniProt ID: B2GT58 |
SIMILARITY: Belongs to the RRM IMP/VICKZ family. {ECO:0000256|ARBA:ARBA00009094}. |
UniProt ID: A0A8M9P1P8 |
SIMILARITY: Belongs to the RRM IMP/VICKZ family. {ECO:0000256|ARBA:ARBA00009094}. |
UniProt ID: Q9PW80 |
FUNCTION: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Involved in neuronal crest migration (PubMed:14522877). {ECO:0000250|UniProtKB:O00425, ECO:0000269|PubMed:14522877}. SUBUNIT: Homodimer and multimer. {ECO:0000250|UniProtKB:O00425}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10525193}. Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O00425}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:O00425}. Note=Accumulates along the vegetal cortex as oogenesis progresses. Colocalizes to extended processes in migrating neuronal crest cells. DEVELOPMENTAL STAGE: Expressed in oocytes from stages I to III. Expressed in 8-cell embryo. Expressed in brain, eye, branchial arches and neural tube at 24 hours post-fertilization (hpf). Detected predominantly in the CNS, putative neural crest, the sensorial layer of the epidermal ectoderm and their derivatives until the tailbud stage. {ECO:0000269|PubMed:10525193, ECO:0000269|PubMed:14522877}. DOMAIN: All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules. {ECO:0000250|UniProtKB:O00425}. SIMILARITY: Belongs to the RRM IMP/VICKZ family. {ECO:0000305}. |
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