ZFIN

ZFIN ID: ZDB-GENE-070622-2

ZFIN ID: ZDB-GENE-070622-2

CITATIONS (74 total)

Gene Name:	ghrelin/obestatin prepropeptide
Gene Symbol:	ghrl

Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201

de Alba, G., Carrillo, S., Sánchez-Vázquez, F.J., López-Olmeda, J.F. (2022) Combined blue light and daily thermocycles enhance zebrafish growth and development. Journal of experimental zoology. Part A, Ecological and integrative physiology. 337(5):501-515

Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109

Athapaththu, A.M.G.K., Molagoda, I.M.N., Jayasooriya, R.G.P.T., Choi, Y.H., Jeon, Y.J., Park, J.H., Lee, B.J., Kim, G.Y. (2021) Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA_A and GABA_B Receptors. International Journal of Molecular Sciences. 22(20):

Hsieh, Y.W., Tsai, Y.W., Lai, H.H., Lai, C.Y., Lin, C.Y., Her, G.M. (2021) Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish. Biomedicines. 9(8):

Montalbano, G., Maugeri, A., Guerrera, M.C., Miceli, N., Navarra, M., Barreca, D., Cirmi, S., Germanà, A. (2021) A White Grape Juice Extract Reduces Fat Accumulation through the Modulation of Ghrelin and Leptin Expression in an In Vivo Model of Overfed Zebrafish. Molecules. 26(4):

Schneider, A.C.R., de Moura, A.C., Carvalho, F.B., Alves, T., Meurer, F., Porawski, M., da Silveira, T.R. (2021) Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose. Zebrafish. 18(3):184-189

Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Huang, J., Wan, X., Guan, W., Su, K.P., Ye, M., Gao, X., Yin, Z., Li, X. (2021) Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brain, behavior, and immunity. 94:327-337

Zarantoniello, M., Randazzo, B., Cardinaletti, G., Truzzi, C., Chemello, G., Riolo, P., Olivotto, I. (2021) Possible Dietary Effects of Insect-Based Diets across Zebrafish (Danio rerio) Generations: A Multidisciplinary Study on the Larval Phase. Animals : an open access journal from MDPI. 11(3):

Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727

Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993

Kwasek, K., Wojno, M., Iannini, F., McCracken, V.J., Molinari, G.S., Terova, G. (2020) Nutritional programming improves dietary plant protein utilization in zebrafish Danio rerio. PLoS One. 15:e0225917

Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109

Molagoda, I.M.N., Jayasingha, J.A.C.C., Choi, Y.H., Park, E.K., Jeon, Y.J., Lee, B.J., Kim, G.Y. (2020) Fermented Oyster Extract Promotes Insulin-Like Growth Factor-1-Mediated Osteogenesis and Growth Rate. Marine drugs. 18(9):

Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698

Rajeswari, J.J., Blanco, A.M., Unniappan, S. (2020) Phoenixin-20 (PNX-20) Suppresses Food Intake, Modulates Glucoregulatory Enzymes, and Enhances Glycolysis in Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R917-R928

Zarantoniello, M., Randazzo, B., Gioacchini, G., Truzzi, C., Giorgini, E., Riolo, P., Gioia, G., Bertolucci, C., Osimani, A., Cardinaletti, G., Lucon-Xiccato, T., Milanović, V., Annibaldi, A., Tulli, F., Notarstefano, V., Ruschioni, S., Clementi, F., Olivotto, I. (2020) Zebrafish (Danio rerio) physiological and behavioural responses to insect-based diets: a multidisciplinary approach. Scientific Reports. 10:10648

Blanco, A.M., Cortés, R., Bertucci, J.I., Soletto, L., Sánchez, E., Valenciano, A.I., Cerdá-Reverter, J.M., Delgado, M.J. (2019) Brain transcriptome profile after CRISPR-induced ghrelin mutations in zebrafish. Fish physiology and biochemistry. 46(1):1-21

Buerger, A.N., Schmidt, J., Chase, A., Paxaio, C., Patel, T.N., Brumback, B.A., Kane, A.S., Martyniuk, C.J., Bisesi, J.H. (2019) Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate. Environmental pollution (Barking, Essex : 1987). 245:1086-1094

Montalbano, G., Mania, M., Guerrera, M.C., Laurà, R., Abbate, F., Levanti, M., Maugeri, A., Germanà, A., Navarra, M. (2019) Effects of a Flavonoid-Rich Extract from Citrus sinensis Juice on a Diet-Induced Obese Zebrafish. International Journal of Molecular Sciences. 20(20):

Opazo, R., Plaza-Parrochia, F., Cardoso Dos Santos, G.R., Carneiro, G.R.A., Sardela, V.F., Romero, J., Valladares, L. (2019) Fasting Upregulates npy, agrp, and ghsr Without Increasing Ghrelin Levels in Zebrafish (Danio rerio) Larvae. Frontiers in Physiology. 9:1901

Ye, L., Mueller, O., Bagwell, J., Bagnat, M., Liddle, R.A., Rawls, J.F. (2019) High fat diet induces microbiota-dependent silencing of enteroendocrine cells. eLIFE. 8:

Montalbano, G., Mania, M., Abbate, F., Navarra, M., Guerrera, M.C., Laura, R., Vega, J.A., Levanti, M., Germanà, A. (2018) Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish. Endocrine. 62(2):381-393

Cortés, R., Teles, M., Oliveira, M., Fierro-Castro, C., Tort, L., Cerdá-Reverter, J.M. (2017) Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish. Fish physiology and biochemistry. 44(1):257-272

Hossein Hoseinifar, S., Safari, R., Dadar, M. (2017) Dietary sodium propionate affects mucosal immune parameters, growth and appetite related genes expression: insights from zebrafish model. General and comparative endocrinology. 243:78-83

Jacobs, H.M., Sant, K.E., Basnet, A., Williams, L.M., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere. 195:498-507

Opazo, R., Fuenzalida, K., Plaza-Parrochia, F., Romero, J. (2017) Performance of Debaryomyces hansenii as a Diet for Rotifers for Feeding Zebrafish Larvae. Zebrafish. 14(2):187-194

Safari, R., Hoseinifar, S.H., Van Doan, H., Dadar, M. (2017) The effects of dietary Myrtle (Myrtus communis) on skin mucus immune parameters and mRNA levels of growth, antioxidant and immune related genes in zebrafish (Danio rerio). Fish & shellfish immunology. 66:264-269

Sant, K.E., Jacobs, H.M., Borofski, K.A., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 220(Pt B):807-817

Sundarrajan, L., Unniappan, S. (2017) Small Interfering RNA Mediated Knockdown of Irisin Suppresses Food Intake and Modulates Appetite Regulatory Peptides in Zebrafish. General and comparative endocrinology. 252:200-208

Tian, J., Wang, K., Wang, X., Wen, H., Zhou, H., Liu, C., Mai, K., He, G. (2017) Soybean Saponin Modulates Nutrient Sensing Pathways and Metabolism in Zebrafish. General and comparative endocrinology. 257:246-254

Dalmolin, C., Almeida, D.V., Figueiredo, M.A., Marins, L.F. (2015) Food intake and appetite control in a GH-transgenic zebrafish. Fish physiology and biochemistry. 41(5):1131-41

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Hatef, A., Shajan, S., Unniappan, S. (2015) Nutrient status modulates the expression of nesfatin-1 encoding nucleobindin 2A and 2B mRNAs in zebrafish gut, liver and brain. General and comparative endocrinology. 215:51-60

Hatef, A., Yufa, R., Unniappan, S. (2015) Ghrelin O-Acyl Transferase in Zebrafish Is an Evolutionarily Conserved Peptide Upregulated During Calorie Restriction. Zebrafish. 12(5):327-38

Tian, J., He, G., Mai, K., Liu, C. (2015) Effects of postprandial starvation on mRNA expression of endocrine-, amino acid and peptide transporter-, and metabolic enzyme-related genes in zebrafish (Danio rerio). Fish physiology and biochemistry. 41(3):773-87

Timme-Laragy, A.R., Sant, K.E., Rousseau, M.E., diIorio, P.J. (2015) Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 178:25-32

Eom, J., Hong, M., Cone, R.D., and Song, Y. (2013) Zebrafish ghrelin is expressed in pancreatic endocrine cells and regulated by metabolic state. Biochemical and Biophysical Research Communications. 439(1):115-20

Feng, K., Zhang, G.R., Wei, K.J., and Xiong, B.X. (2013) Molecular Cloning, Tissue Distribution, and Ontogenetic Expression of Ghrelin and Regulation of Expression by Fasting and Refeeding in the Grass Carp (Ctenopharyngodon idellus). Journal of experimental zoology. Part A, Ecological genetics and physiology. 319(4):202-12

Flasse, L., Stern, D.G., Pirson, J.L., Manfroid, I., Peers, B., and Voz, M.L. (2013) The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine. Developmental Biology. 376(2):187-197

Flasse, L.C., Pirson, J.L., Stern, D.G., Von Berg, V., Manfroid, I., Peers, B., and Voz, M.L. (2013) Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biology. 11(1):78

Liu, Y., Li, S., Huang, X., Lu, D., Liu, X., Ko, W.H., Zhang, Y., Cheng, C.H., and Lin, H. (2013) Identification and characterization of a motilin-like peptide and its receptor in teleost. General and comparative endocrinology. 186:85-93

Sanden, M., Ornsrud, R., Sissener, N.H., Jorgensen, S., Gu, J., Bakke, A.M., and Hemre, G.I. (2013) Cross-generational feeding of Bt (Bacillus thuringiensis)-maize to zebrafish (Danio rerio) showed no adverse effects on the parental or offspring generations. The British journal of nutrition. 110(12):2222-33

Wilfinger, A., Arkhipova, V., and Meyer, D. (2013) Cell type and tissue specific function of islet genes in zebrafish pancreas development. Developmental Biology. 378(1):25-37

Djiotsa, J., Verbruggen, V., Giacomotto, J., Ishibashi, M., Manning, E., Rinkwitz, S., Manfroid, I., Lvoz, M., and Peers, B. (2012) Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Developmental Biology. 12(1):37

Koven, W., and Schulte, P. (2012) The effect of fasting and refeeding on mRNA expression of PepT1 and gastrointestinal hormones regulating digestion and food intake in zebrafish (Danio rerio). Fish physiology and biochemistry. 38(6):1565-1575

Anderson, K.R., Singer, R.A., Balderes, D.A., Hernandez-Lagunas, L., Johnson, C.W., Artinger, K.B., and Sussel, L. (2011) The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (Cambridge, England). 138(15):3213-3224

Dalgin, G., Ward, A.B., Hao le, T., Beattie, C.E., Nechiporuk, A., and Prince, V.E. (2011) Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development (Cambridge, England). 138(21):4597-4608

Binot, A.C., Manfroid, I., Flasse, L., Winandy, M., Motte, P., Martial, J.A., Peers, B., and Voz, M.L. (2010) Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells. Developmental Biology. 340(2):397-407

Carnevali, O., Gioacchini, G., Piccinetti, C.C., Maradonna, F., Lombardo, F., Giorgini, E., and Tosi, G. (2010) Melatonin control of oogenesis and metabolic resources in Zebrafish. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(5):826-830

Cruz, S.A., Tseng, Y.C., Kaiya, H., Hwang, P.P., Cruz, S.A., Hwang, P.P., Kaiya, H., Tseng, Y.C., and Hwang, P.P. (2010) Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 156(2):190-200

Piccinetti, C.C., Migliarini, B., Olivotto, I., Coletti, G., Amici, A., and Carnevali, O. (2010) Appetite regulation: The central role of melatonin in Danio rerio. Hormones and behavior. 58(5):780-785

Ragvin, A., Moro, E., Fredman, D., Navratilova, P., Drivenes, O., Engström, P.G., Alonso, M.E., Mustienes, E.D., Gomez Skarmeta, J.L., Tavares, M.J., Casares, F., Manzanares, M., van Heyningen, V., Molven, A., Njølstad, P.R., Argenton, F., Lenhard, B., and Becker, T.S. (2010) Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proceedings of the National Academy of Sciences of the United States of America. 107(2):775-780

Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M.L., Mellitzer, G., and Gradwohl, G. (2010) Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England). 137(2):203-212

Verbruggen, V., Ek, O., Georlette, D., Delporte, F., Von Berg, V., Detry, N., Biemar, F., Coutinho, P., Martial, J.A., Voz, M.L., Manfroid, I., and Peers, B. (2010) The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish. The Journal of biological chemistry. 285(18):13863-13873

Amole, N., and Unniappan, S. (2009) Fasting induces preproghrelin mRNA expression in the brain and gut of zebrafish, Danio rerio. General and comparative endocrinology. 161(1):133-137

Li, X., He, J., Hu, W., and Yin, Z. (2009) The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-2774

Delporte, F.M., Pasque, V., Devos, N., Manfroid, I., Voz, M.L., Motte, P., Biemar, F., Martial, J.A., and Peers, B. (2008) Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors. BMC Developmental Biology. 8:53

Kaiya, H., Miyazato, M., Kangawa, K., Peter, R.E., and Unniappan, S. (2008) Ghrelin: a multifunctional hormone in non-mammalian vertebrates. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 149(2):109-128

Olsson, C., Holbrook, J.D., Bompadre, G., Jönsson, E., Hoyle, C.H., Sanger, G.J., Holmgren, S., and Andrews, P.L. (2008) Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. General and comparative endocrinology. 155(1):217-226

Pauls, S., Zecchin, E., Tiso, N., Bortolussi, M., and Argenton, F. (2007) Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Developmental Biology. 304(2):875-890

Kojima, M., and Kangawa, K. (2005) Ghrelin: structure and function. Physiological reviews. 85(2):495-522

Additional Citations (12):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.