ZFIN

ZFIN ID: ZDB-GENE-070521-8

CITATIONS (49 total)

Gene Name:	apelin
Gene Symbol:	apln

Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201

El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029

Qi, J., Rittershaus, A., Priya, R., Mansingh, S., Stainier, D.Y.R., Helker, C.S.M. (2022) Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. eLIFE. 11:

Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):

Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):

Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589

Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166

Iwasaki, R., Tsuge, K., Kishimoto, K., Hayashi, Y., Iwaana, T., Hohjoh, H., Inazumi, T., Kawahara, A., Tsuchiya, S., Sugimoto, Y. (2019) Essential role of prostaglandin E₂ and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. Scientific Reports. 9:7650

Marín-Juez, R., El-Sammak, H., Helker, C.S.M., Kamezaki, A., Mullapuli, S.T., Bibli, S.I., Foglia, M.J., Fleming, I., Poss, K.D., Stainier, D.Y.R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Developmental Cell. 51:503-515.e4

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239

Feng, X., Yu, X., Fu, B., Wang, X., Liu, H., Pang, M., Tong, J. (2018) A high-resolution genetic linkage map and QTL fine mapping for growth-related traits and sex in the Yangtze River common carp (Cyprinus carpio haematopterus). BMC Genomics. 19:230

Gauvrit, S., Villasenor, A., Strilic, B., Kitchen, P., Collins, M.M., Marín-Juez, R., Guenther, S., Maischein, H.M., Fukuda, N., Canham, M.A., Brickman, J.M., Bogue, C.W., Jayaraman, P.S., Stainier, D.Y.R. (2018) HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. Nature communications. 9:2704

Zhang, J., Wan, Y., Fang, C., Chen, J., Ouyang, W., Li, J., Wang, Y. (2018) The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates. Biochemical and Biophysical Research Communications. 501(2):408-414

Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756

Lu, L., Cao, J., Li, L., Chen, L. (2017) Elabela, a new endogenous ligand of APJ, functions in embryos and adults organisms. Acta biochimica et biophysica Sinica. 49:378-381

Rovira, M., Arrey, G., Planas, J.V. (2017) Exercise-Induced Hypertrophic and Oxidative Signaling Pathways and Myokine Expression in Fast Muscle of Adult Zebrafish. Frontiers in Physiology. 8:1063

Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887

Kwon, H.B., Wang, S., Helker, C.S., Rasouli, S.J., Maischein, H.M., Offermanns, S., Herzog, W., Stainier, D.Y. (2016) In vivo modulation of endothelial polarization by Apelin receptor signalling. Nature communications. 7:11805

Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Helker, C.S., Schuermann, A., Pollmann, C., Chng, S.C., Kiefer, F., Reversade, B., Herzog, W. (2015) The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis. eLIFE. 4

Kim, J.D., Kang, Y., Kim, J., Papangeli, I., Kang, H., Wu, J., Park, H., Nadelmann, E., Rockson, S.G., Chun, H.J., and Jin, S.W. (2014) Essential role of apelin signaling during lymphatic development in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 34(2):338-345

Pauli, A., Norris, M.L., Valen, E., Chew, G.L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., and Schier, A.F. (2014) Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science (New York, N.Y.). 343(6172):1248636

Chng, S.C., Ho, L., Tian, J., and Reversade, B. (2013) ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor. Developmental Cell. 27(6):672-680

Del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J.S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., Penninger, J., and Eichmann, A. (2010) Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116(19):4025-4033

Volkoff, H., and Wyatt, J.L. (2009) Apelin in goldfish (Carassius auratus): cloning, distribution and role in appetite regulation. Peptides. 30(8):1434-1440

Eyries, M., Siegfried, G., Ciumas, M., Montagne, K., Agrapart, M., Lebrin, F., and Soubrier, F. (2008) Hypoxia-Induced Apelin Expression Regulates Endothelial Cell Proliferation and Regenerative Angiogenesis. Circulation research. 103(4):432-440

Moon, M.J., Oh, D.Y., Moon, J.S., Kim, D.K., Hwang, J.I., Lee, J.Y., Kim, J.I., Cho, S., Kwon, H.B., and Seong, J.Y. (2007) Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13. Molecular and Cellular Endocrinology. 277(1-2):51-60

Quertermous, T. (2007) Apelin and its G protein-coupled receptor regulate cardiac development as well as cardiac function. Developmental Cell. 12(3):319-320

Scott, I.C., Masri, B., D'Amico, L.A., Jin, S.W., Jungblut, B., Wehman, A.M., Baier, H., Audigier, Y., and Stainier, D.Y. (2007) The G protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Developmental Cell. 12(3):403-413

Zeng, X.X., Wilm, T.P., Sepich, D.S., and Solnica-Krezel, L. (2007) Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation. Developmental Cell. 12(3):391-402

Additional Citations (17):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.