ZFIN

ZFIN ID: ZDB-GENE-050705-1

ZFIN ID: ZDB-GENE-050705-1

CITATIONS (61 total)

Gene Name:	cytochrome P450, family 1, subfamily C, polypeptide 2
Gene Symbol:	cyp1c2

Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344

Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):

Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356

Moura-Alves, P., Puyskens, A., Stinn, A., Klemm, M., Guhlich-Bornhof, U., Dorhoi, A., Furkert, J., Kreuchwig, A., Protze, J., Lozza, L., Pei, G., Saikali, P., Perdomo, C., Mollenkopf, H.J., Hurwitz, R., Kirschhoefer, F., Brenner-Weiss, G., Weiner, J., Oschkinat, H., Kolbe, M., Krause, G., Kaufmann, S.H.E. (2019) Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science (New York, N.Y.). 366(6472):

He, Y., Sun, C., Zhang, Y., Folkerts, E.J., Martin, J.W., Goss, G.G. (2018) Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish (Danio rerio). Environmental science & technology. 52(6):3820-3830

Jia, Z.Q., Liu, D., Sheng, C.W., Casida, J.E., Wang, C., Song, P.P., Chen, Y.M., Han, Z.J., Zhao, C.Q. (2018) Acute toxicity, bioconcentration, elimination and antioxidant effects of fluralaner in zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 232:183-190

Meyer-Alert, H., Ladermann, K., Larsson, M., Schiwy, S., Hollert, H., Keiter, S.H. (2018) A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 204:117-129

Verbueken, E., Bars, C., Ball, J.S., Periz-Stanacev, J., Marei, W.F.A., Tochwin, A., Gabriëls, I.J., Michiels, E.D.G., Stinckens, E., Vergauwen, L., Knapen, D., Van Ginneken, C.J., Van Cruchten, S.J. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences. 19(12)

Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W. (2017) Biotransformation in the zebrafish embryo -temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene. Environmental pollution (Barking, Essex : 1987). 230:1-11

Verbueken, E., Alsop, D., Saad, M.A., Pype, C., Van Peer, E.M., Casteleyn, C.R., Van Ginneken, C.J., Wilson, J., Van Cruchten, S.J. (2017) In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. International Journal of Molecular Sciences. 18(1)

Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced cyp1a mRNA in zebrafish larvae.. Toxicology reports. 4:614-624

Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146

Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572

Zhou, Z., Yang, J., Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 191:175-188

Truong, L., Bugel, S.M., Chlebowski, A., Usenko, C.Y., Simonich, M.T., Massey Simonich, S.L., Tanguay, R.L. (2016) Optimizing multi-dimensional high throughput screening using zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:139-147

Wincent, E., Kubota, A., Timme-Laragy, A., Jönsson, M.E., Hahn, M.E., Stegeman, J.J. (2016) Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochemical pharmacology. 110-111:117-29

Xia, L., Zheng, L., Zhou, J.L. (2016) Transcriptional and morphological effects of tamoxifen on the early development of zebrafish (Danio rerio). Journal of applied toxicology : JAT. 36(6):853-62

Yang, J., Zhu, J., Chan, K.M. (2016) BDE-99, but not BDE-47, is a Transient Aryl Hydrocarbon Receptor Agonist in Zebrafish Liver Cells. Toxicology and applied pharmacology. 305:203-15

Yang, Y., Ye, X., He, B., Liu, J. (2016) Cadmium potentiates toxicity of cypermethrin in zebrafish. Environmental toxicology and chemistry. 35(2):435-45

Bräunig, J., Schiwy, S., Broedel, O., Müller, Y., Frohme, M., Hollert, H., Keiter, S.H. (2015) Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio). Environmental science and pollution research international. 22(21):16319-28

Schiwy, S., Bräunig, J., Alert, H., Hollert, H., Keiter, S.H. (2015) A novel contact assay for testing aryl hydrocarbon receptor (AhR)-mediated toxicity of chemicals and whole sediments in zebrafish (Danio rerio) embryos. Environmental science and pollution research international. 22(21):16305-18

Stegeman, J.J., Behrendt, L., Woodin, B.R., Kubota, A., Lemaire, B., Pompon, D., Goldstone, J.V., Urban, P. (2015) Functional Characterization of Zebrafish Cytochrome P450 1 Family Proteins Expressed in Yeast. Biochimica et biophysica acta. General subjects. 1850(11):2340-52

Wincent, E., Jonsson, M., Bottai, M., Lundstedt, S., Dreij, K. (2015) Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs. Environmental science & technology. 49(6):3869-77

Šrut, M., Bourdineaud, J.P., Štambuk, A., Klobučar, G.I. (2015) Genomic and gene expression responses to genotoxic stress in PAC2 zebrafish embryonic cell line. Journal of applied toxicology : JAT. 35(11):1381-9

Blüthgen, N., Meili, N., Chew, G., Odermatt, A., and Fent, K. (2014) Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). The Science of the total environment. 476-477:207-217

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Chang, C.T., Chung, H.Y., Su, H.T., Tseng, H.P., Tzou, W.S., and Hu, C.H. (2013) Regulation of zebrafish CYP3A65 transcription by AHR2. Toxicology and applied pharmacology. 270(2):174-184

Goodale, B.C., Tilton, S.C., Corvi, M.M., Wilson, G.R., Janszen, D.B., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicology and applied pharmacology. 272(3):656-70

Knecht, A.L., Goodale, B.C., Truong, L., Simonich, M.T., Swanson, A.J., Matzke, M.M., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicology and applied pharmacology. 271(2):266-75

Yuan, L., Lv, B., Zha, J., Wang, Z., Wang, W., Li, W., and Zhu, L. (2013) New cytochrome P450 1B1, 1C1, 2Aa, 2Y3, and 2K genes from Chinese rare minnow (Gobiocypris rarus): Molecular characterization, basal expression and response of rare minnow CYP1s and CYP2s mRNA exposed to the AHR agonist benzo[a]pyrene. Chemosphere. 93(2):209-16

Goodale, B.C., La Du, J.K., Bisson, W.H., Janszen, D.B., Waters, K.M., and Tanguay, R.L. (2012) AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish. PLoS One. 7(1):e29346

Harskamp, J., Britz-McKibbin, P., and Wilson, J.Y. (2012) Functional Screening of Cytochrome P450 Activity and Uncoupling by Capillary Electrophoresis. Analytical chemistry. 84(2):862-866

Smith, E.M., Iftikar, F.I., Higgins, S., Irshad, A., Jandoc, R., Lee, M., and Wilson, J.Y. (2012) In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes. Aquatic toxicology (Amsterdam, Netherlands). 109:259-266

Gao, K., Brandt, I., Goldstone, J.V., and Jönsson, M.E. (2011) Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 154(1):42-55

Jönsson, M.E., Woodin, B.R., Stegeman, J.J., and Brunström, B. (2011) Cytochrome p450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos. PLoS One. 6(12):e28257

Kubota, A., Stegeman, J.J., Woodin, B.R., Iwanaga, T., Harano, R., Peterson, R.E., Hiraga, T., and Teraoka, H. (2011) Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2. Toxicology and applied pharmacology. 253(3):244-52

Behrendt, L., Jönsson, M.E., Goldstone, J.V., and Stegeman, J.J. (2010) Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation. Aquatic toxicology (Amsterdam, Netherlands). 98(1):74-82

Bugiak, B.J., and Weber, L.P. (2010) Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 99(3):423-437

Goldstone, J.V., McArthur, A.G., Kubota, A., Zanette, J., Parente, T., Jonsson, M.E., Nelson, D.R., and Stegeman, J.J. (2010) Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish. BMC Genomics. 11:643

Scornaienchi, M.L., Thornton, C., Willett, K.L., and Wilson, J.Y. (2010) Cytochrome P450-mediated 17β-estradiol metabolism in zebrafish (Danio rerio). The Journal of endocrinology. 206(3):317-325

Scornaienchi, M.L., Thornton, C., Willett, K.L., and Wilson, J.Y. (2010) Functional differences in the cytochrome P450 1 family enzymes from Zebrafish (Danio rerio) using heterologously expressed proteins. Archives of biochemistry and biophysics. 502(1):17-22

Bugiak, B., and Weber, L.P. (2009) Hepatic and vascular mRNA expression in adult zebrafish (Danio rerio) following exposure to benzo-a-pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Aquatic toxicology (Amsterdam, Netherlands). 95(4):299-306

Jönsson, M.E., Franks, D.G., Woodin, B.R., Jenny, M.J., Garrick, R.A., Behrendt, L., Hahn, M.E., and Stegeman, J.J. (2009) The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. Chemico-biological interactions. 181(3):447-454

Goldstone, J.V., Goldstone, H.M., Morrison, A.M., Tarrant, A., Kern, S.E., Woodin, B.R., and Stegeman, J.J. (2007) Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol. Biol. Evol.. 24(12):2619-2631

Jonsson, M.E., Orrego, R., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2007) Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicology and applied pharmacology. 221(1):29-41

Jönsson, M.E., Jenny, M.J., Woodin, B.R., Hahn, M.E., and Stegeman, J.J. (2007) Role of AHR2 in the Expression of Novel Cytochrome P450 1 Family Genes, Cell Cycle Genes, and Morphological Defects in Developing Zebrafish Exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 100(1):180-193

Godard, C.A., Goldstone, J.V., Said, M.R., Dickerson, R.L., Woodin, B.R., and Stegeman, J.J. (2005) The new vertebrate CYP1C family: Cloning of new subfamily members and phylogenetic analysis. Biochemical and Biophysical Research Communications. 331(4):1016-1024

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (13):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.