Research
Search
Genes / Clones
Expression
Mutants / Tg
Antibodies
Anatomy / GO / Human Disease / Chemical
Publications
Data Mining
Downloads
Data Model
AllianceMine
BioMart
Genomics
BLAST
ZFIN
Ensembl
NCBI
UCSC
Genome Browsers
ZFIN
Ensembl
Vega
GRC
UCSC
NCBI
Resources
Zebrafish Genomics
Other Genome Databases
Resources
General
The Zebrafish Book
Protocol Wiki
Antibody Wiki
Anatomy Atlases
Resources for Students and Educators
Zebrafish Programs
ZF-Health
Husbandry Resources
More...
Resource Centers
Zebrafish International Resource Center (ZIRC)
China Zebrafish Resource Center (CZRC)
European Zebrafish Resource Center (EZRC)
Community
Announcements
News
Meetings
Jobs
Alliance Community Forum
Search
People
Labs
Companies
Societies
International Zebrafish Society (IZFS)
Zebrafish Disease Models Society (ZDMS)
Genetics Society of America (GSA)
Zebrafish Husbandry Association
Support
Nomenclature
Nomenclature Conventions
Line Designations
Wild-Type Lines
Submit a Proposed Gene Name
Submit a Proposed Mutant/Tg Line Name
Publications
Guidelines for Authors
Zebrashare
Citing ZFIN
Using ZFIN
Help & Tips
Glossary
Single Box Search Help
Submit Data
Terms of Use
About Us
About ZFIN
Contact Information
Statistics
Committees
Jobs at ZFIN
Sign In
ZFIN ID:
ZDB-GENE-040623-1
CITATIONS
(41 total)
Gene Name:
parathyroid hormone 1a
Gene Symbol:
pth1a
Aceto, J., Nourizadeh-Lillabadi, R., Marée, R., Dardenne, N., Jeanray, N., Wehenkel, L., Aleström, P., van Loon, J.J., Muller, M. (2015) Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. PLoS One. 10:e0126928
Anneser, L., Alcantara, I.C., Gemmer, A., Mirkes, K., Ryu, S., Schuman, E.M. (2020) The neuropeptide Pth2 dynamically senses others via mechanosensation. Nature. 588(7839):653-657
Bhattacharya, P., Yan, Y.L., Postlethwait, J., and Rubin, D. (2011) Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. The Journal of endocrinology. 211(2):187-200
Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900
Catchen, J.M., Conery, J.S., and Postlethwait, J.H. (2009) Automated identification of conserved synteny after whole-genome duplication. Genome research. 19(8):1497-1505
Faria, M., Prats, E., Padrós, F., Soares, A.M., Raldúa, D. (2017) Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Archives of toxicology. 91(4):1891-1901
Gensure, R.C., Ponugoti, B., Gunes, Y., Papasani, M.R., Lanske, B., Bastepe, M., Rubin, D.A., and Jüppner, H. (2004) Identification and Characterization of Two Parathyroid Hormone-Like Molecules in Zebrafish. Endocrinology. 145(4):1634-1639
Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
Hogan, B.M., Danks, J.A., Layton, J.E., Hall, N.E., Heath, J.K., and Lieschke, G.J. (2005) Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis. Endocrinology. 146(2):547-551
Hoshijima, K., and Hirose, S. (2007) Expression of endocrine genes in zebrafish larvae in response to environmental salinity. The Journal of endocrinology. 193(3):481-491
Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
Kumai, Y., Kwong, R.W., Perry, S.F. (2015) A role for transcription factor glial cell missing 2 in Ca(2+) homeostasis in zebrafish, Danio rerio. Pflugers Archiv : European journal of physiology. 467(4):753-65
Kwong, R.W., Auprix, D., and Perry, S.F. (2014) Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. American journal of physiology. Regulatory, integrative and comparative physiology. 306(4):R211-R221
Kwong, R.W., Perry, S.F. (2015) An essential role for parathyroid hormone in gill formation and differentiation of ion-transporting cells in developing zebrafish. Endocrinology. 156(7):2384-94
Lee, C.Y., Horng, J.L., Liu, S.T., Lin, L.Y. (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere. 261:128051
Lin, C.H., Su, C.H., and Hwang, P.P. (2014) Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 155(1):56-67
Okabe, M., and Graham, A. (2004) The origin of the parathyroid gland. Proceedings of the National Academy of Sciences of the United States of America. 101(51):17716-17719
On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
Papasani, M.R., Gensure, R.C., Yan, Y.L., Gunes, Y., Postlethwait, J.H., Ponugoti, B., John, M.R., Jüppner, H., and Rubin, D.A. (2004) Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39 (TIP39). Endocrinology. 145(11):5294-5304
Pillar, N., Pleniceanu, O., Fang, M., Ziv, L., Lahav, E., Botchan, S., Cheng, L., Dekel, B., Shomron, N. (2017) A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Human genetics. 136(7):835-845
Pinheiro, P. L., Cardoso, J.C., Power, D.M., Canário, A.V. (2012) Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evolutionary Biology. 12:110
Qiu, W., Liu, S., Chen, H., Luo, S., Xiong, Y., Wang, X., Xu, B., Zheng, C., Wang, K.J. (2020) The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms. Journal of hazardous materials. 406:124303
Renn, J., Winkler, C., Schartl, M., Fischer, R., and Goerlich, R. (2006) Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 229(2-4):209-214
Suarez-Bregua, P., Cal, L., Cañestro, C., Rotllant, J. (2017) PTH Reloaded: A New Evolutionary Perspective. Frontiers in Physiology. 8:776
Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
Wang, B., Liu, L., Li, Y., Zou, J., Li, D., Zhao, D., Li, W., Sun, W. (2021) Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Toxicology. 456:152786
Wang, H. (2009) Comparative genomic analysis of teleost fish bmal genes. Genetica. 136(1):149-161
Xu, T., Zhao, J., Yin, D., Zhao, Q., Dong, B. (2015) High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 16:23
Yan, Y.L., Bhattacharya, P., He, X., Ponugoti, B., Marquardt, B., Layman, J., Grunloh, M., Postlethwait, J.H., and Rubin, D. (2012) Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. The Journal of endocrinology. 214(3):421-435
Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900
Wang, B., Liu, L., Li, Y., Zou, J., Li, D., Zhao, D., Li, W., Sun, W. (2021) Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Toxicology. 456:152786
Anneser, L., Alcantara, I.C., Gemmer, A., Mirkes, K., Ryu, S., Schuman, E.M. (2020) The neuropeptide Pth2 dynamically senses others via mechanosensation. Nature. 588(7839):653-657
Lee, C.Y., Horng, J.L., Liu, S.T., Lin, L.Y. (2020) Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. Chemosphere. 261:128051
Qiu, W., Liu, S., Chen, H., Luo, S., Xiong, Y., Wang, X., Xu, B., Zheng, C., Wang, K.J. (2020) The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms. Journal of hazardous materials. 406:124303
Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
Faria, M., Prats, E., Padrós, F., Soares, A.M., Raldúa, D. (2017) Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Archives of toxicology. 91(4):1891-1901
Pillar, N., Pleniceanu, O., Fang, M., Ziv, L., Lahav, E., Botchan, S., Cheng, L., Dekel, B., Shomron, N. (2017) A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Human genetics. 136(7):835-845
Suarez-Bregua, P., Cal, L., Cañestro, C., Rotllant, J. (2017) PTH Reloaded: A New Evolutionary Perspective. Frontiers in Physiology. 8:776
Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
Aceto, J., Nourizadeh-Lillabadi, R., Marée, R., Dardenne, N., Jeanray, N., Wehenkel, L., Aleström, P., van Loon, J.J., Muller, M. (2015) Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. PLoS One. 10:e0126928
Kumai, Y., Kwong, R.W., Perry, S.F. (2015) A role for transcription factor glial cell missing 2 in Ca(2+) homeostasis in zebrafish, Danio rerio. Pflugers Archiv : European journal of physiology. 467(4):753-65
Kwong, R.W., Perry, S.F. (2015) An essential role for parathyroid hormone in gill formation and differentiation of ion-transporting cells in developing zebrafish. Endocrinology. 156(7):2384-94
On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
Xu, T., Zhao, J., Yin, D., Zhao, Q., Dong, B. (2015) High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC Genomics. 16:23
Kwong, R.W., Auprix, D., and Perry, S.F. (2014) Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. American journal of physiology. Regulatory, integrative and comparative physiology. 306(4):R211-R221
Lin, C.H., Su, C.H., and Hwang, P.P. (2014) Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 155(1):56-67
Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
Pinheiro, P. L., Cardoso, J.C., Power, D.M., Canário, A.V. (2012) Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evolutionary Biology. 12:110
Yan, Y.L., Bhattacharya, P., He, X., Ponugoti, B., Marquardt, B., Layman, J., Grunloh, M., Postlethwait, J.H., and Rubin, D. (2012) Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. The Journal of endocrinology. 214(3):421-435
Bhattacharya, P., Yan, Y.L., Postlethwait, J., and Rubin, D. (2011) Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. The Journal of endocrinology. 211(2):187-200
Catchen, J.M., Conery, J.S., and Postlethwait, J.H. (2009) Automated identification of conserved synteny after whole-genome duplication. Genome research. 19(8):1497-1505
Wang, H. (2009) Comparative genomic analysis of teleost fish bmal genes. Genetica. 136(1):149-161
Hoshijima, K., and Hirose, S. (2007) Expression of endocrine genes in zebrafish larvae in response to environmental salinity. The Journal of endocrinology. 193(3):481-491
Renn, J., Winkler, C., Schartl, M., Fischer, R., and Goerlich, R. (2006) Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 229(2-4):209-214
Hogan, B.M., Danks, J.A., Layton, J.E., Hall, N.E., Heath, J.K., and Lieschke, G.J. (2005) Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis. Endocrinology. 146(2):547-551
Gensure, R.C., Ponugoti, B., Gunes, Y., Papasani, M.R., Lanske, B., Bastepe, M., Rubin, D.A., and Jüppner, H. (2004) Identification and Characterization of Two Parathyroid Hormone-Like Molecules in Zebrafish. Endocrinology. 145(4):1634-1639
Okabe, M., and Graham, A. (2004) The origin of the parathyroid gland. Proceedings of the National Academy of Sciences of the United States of America. 101(51):17716-17719
Papasani, M.R., Gensure, R.C., Yan, Y.L., Gunes, Y., Postlethwait, J.H., Ponugoti, B., John, M.R., Jüppner, H., and Rubin, D.A. (2004) Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39 (TIP39). Endocrinology. 145(11):5294-5304
Additional Citations (12):
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
Your Input Welcome
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Name:
Institution:
Email address:
Please leave blank:
Subject:
Comments:
Send your comments
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.