Research
Search
Genes / Clones
Expression
Mutants / Tg
Antibodies
Anatomy / GO / Human Disease / Chemical
Publications
Data Mining
Downloads
Data Model
AllianceMine
BioMart
Genomics
BLAST
ZFIN
Ensembl
NCBI
UCSC
Genome Browsers
ZFIN
Ensembl
Vega
GRC
UCSC
NCBI
Resources
Zebrafish Genomics
Other Genome Databases
Resources
General
The Zebrafish Book
Protocol Wiki
Antibody Wiki
Anatomy Atlases
Resources for Students and Educators
Zebrafish Programs
ZF-Health
Husbandry Resources
More...
Resource Centers
Zebrafish International Resource Center (ZIRC)
China Zebrafish Resource Center (CZRC)
European Zebrafish Resource Center (EZRC)
Community
Announcements
News
Meetings
Jobs
Alliance Community Forum
Search
People
Labs
Companies
Societies
International Zebrafish Society (IZFS)
Zebrafish Disease Models Society (ZDMS)
Genetics Society of America (GSA)
Zebrafish Husbandry Association
Support
Nomenclature
Nomenclature Conventions
Line Designations
Wild-Type Lines
Submit a Proposed Gene Name
Submit a Proposed Mutant/Tg Line Name
Publications
Guidelines for Authors
Zebrashare
Citing ZFIN
Using ZFIN
Help & Tips
Glossary
Single Box Search Help
Submit Data
Terms of Use
About Us
About ZFIN
Contact Information
Statistics
Committees
Jobs at ZFIN
Sign In
ZFIN ID:
ZDB-GENE-040219-11
CITATIONS
(32 total)
Gene Name:
toll-like receptor 7
Gene Symbol:
tlr7
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
Chang, M.X., and Nie, P. (2008) RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology and Immunopathology. 124(3-4):295-301
Chang, M.X., Wang, Y.P., and Nie, P. (2009) Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish & shellfish immunology. 26(2):264-274
Esancy, K., Condon, L., Feng, J., Kimball, C., Curtright, A., Dhaka, A. (2018) A zebrafish and mouse model for selective pruritus via direct activation of TRPA1. eLIFE. 7
Jault, C., Pichon, L., and Chluba, J. (2004) Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Molecular immunology. 40(11):759-771
Lee, P.T., Zou, J., Holland, J.W., Martin, S.A., Kanellos, T., and Secombes, C.J. (2013) Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar). Developmental and comparative immunology. 41(2):295-305
Lee, S.H., Peng, K.C., Lee, L.H., Pan, C.Y., Hour, A.L., Her, G.M., Hui, C.F., and Chen, J.Y. (2013) Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Veterinary Immunology and Immunopathology. 151(3-4):217-228
Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962
Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783
Palti, Y., Gahr, S.A., Purcell, M.K., Hadidi, S., Rexroad, C.E. 3rd, and Wiens, G.D. (2010) Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss). Developmental and comparative immunology. 34(2):219-233
Peña, O.A., Lubin, A., Hockings, C., Rowell, J., Jung, Y., Hoade, Y., Dace, P.E.I., Valdivia, L.E., Tuschl, K., Boiers, C., Virgilio, M., Richardson, S.E., Payne, E.M. (2021) TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling. Blood advances. 5(20):4112-4124
Phelps, H.A., and Neely, M.N. (2005) Evolution of the Zebrafish Model: From Development to Immunity and Infectious Disease. Zebrafish. 2(2):87-103
Pietretti, D., Scheer, M., Fink, I.R., Taverne, N., Savelkoul, H.F., Spaink, H.P., Forlenza, M., and Wiegertjes, G.F. (2014) Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 66(2):123-141
Tanekhy, M., Kono, T., and Sakai, M. (2010) Cloning, characterization, and expression analysis of Toll-like receptor-7 cDNA from common carp, Cyprinus carpio L. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 5(4):245-255
Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
van der Sar, A.M., Stockhammer, O.W., van der Laan, C., Spaink, H.P., Bitter, W., and Meijer, A.H. (2006) MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model. Infection and Immunity. 74(4):2436-2441
Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40
Veetil, A.T., Zou, J., Henderson, K.W., Jani, M.S., Shaik, S.M., Sisodia, S.S., Hale, M.E., Krishnan, Y. (2020) DNA-based fluorescent probes of NOS2 activity in live brains. Proceedings of the National Academy of Sciences of the United States of America. 117(26):14694-14702
Wang, B., Liu, X., Zhao, J., Cao, M., Yu, Z., Fu, Q., Tan, F., Yang, N., Li, C. (2022) Characterization, evolution and expression analysis of Toll-like receptor 7 (TLR7) in turbot (Scophthalmus maximus L.). Fish & shellfish immunology. 125:9-16
Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962
Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
Wang, B., Liu, X., Zhao, J., Cao, M., Yu, Z., Fu, Q., Tan, F., Yang, N., Li, C. (2022) Characterization, evolution and expression analysis of Toll-like receptor 7 (TLR7) in turbot (Scophthalmus maximus L.). Fish & shellfish immunology. 125:9-16
Peña, O.A., Lubin, A., Hockings, C., Rowell, J., Jung, Y., Hoade, Y., Dace, P.E.I., Valdivia, L.E., Tuschl, K., Boiers, C., Virgilio, M., Richardson, S.E., Payne, E.M. (2021) TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling. Blood advances. 5(20):4112-4124
Veetil, A.T., Zou, J., Henderson, K.W., Jani, M.S., Shaik, S.M., Sisodia, S.S., Hale, M.E., Krishnan, Y. (2020) DNA-based fluorescent probes of NOS2 activity in live brains. Proceedings of the National Academy of Sciences of the United States of America. 117(26):14694-14702
Esancy, K., Condon, L., Feng, J., Kimball, C., Curtright, A., Dhaka, A. (2018) A zebrafish and mouse model for selective pruritus via direct activation of TRPA1. eLIFE. 7
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
Pietretti, D., Scheer, M., Fink, I.R., Taverne, N., Savelkoul, H.F., Spaink, H.P., Forlenza, M., and Wiegertjes, G.F. (2014) Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 66(2):123-141
Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40
Lee, P.T., Zou, J., Holland, J.W., Martin, S.A., Kanellos, T., and Secombes, C.J. (2013) Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar). Developmental and comparative immunology. 41(2):295-305
Lee, S.H., Peng, K.C., Lee, L.H., Pan, C.Y., Hour, A.L., Her, G.M., Hui, C.F., and Chen, J.Y. (2013) Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Veterinary Immunology and Immunopathology. 151(3-4):217-228
Palti, Y., Gahr, S.A., Purcell, M.K., Hadidi, S., Rexroad, C.E. 3rd, and Wiens, G.D. (2010) Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss). Developmental and comparative immunology. 34(2):219-233
Tanekhy, M., Kono, T., and Sakai, M. (2010) Cloning, characterization, and expression analysis of Toll-like receptor-7 cDNA from common carp, Cyprinus carpio L. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 5(4):245-255
Chang, M.X., Wang, Y.P., and Nie, P. (2009) Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish & shellfish immunology. 26(2):264-274
Chang, M.X., and Nie, P. (2008) RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology and Immunopathology. 124(3-4):295-301
van der Sar, A.M., Stockhammer, O.W., van der Laan, C., Spaink, H.P., Bitter, W., and Meijer, A.H. (2006) MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model. Infection and Immunity. 74(4):2436-2441
Phelps, H.A., and Neely, M.N. (2005) Evolution of the Zebrafish Model: From Development to Immunity and Infectious Disease. Zebrafish. 2(2):87-103
Jault, C., Pichon, L., and Chluba, J. (2004) Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Molecular immunology. 40(11):759-771
Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783
Additional Citations (13):
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
Your Input Welcome
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Name:
Institution:
Email address:
Please leave blank:
Subject:
Comments:
Send your comments
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.