Ai, K., Luo, K., Li, Y., Hu, W., Gao, W., Fang, L., Tian, G., Ruan, G., Xu, Q. (2017) Expression pattern analysis of IRF4 and its related genes revealed the functional differentiation of IRF4 paralogues in teleost. Fish & shellfish immunology. 60:59-64
|
Ai, K., Luo, K., Xia, L., Gao, W., Hu, W., Qi, Z., Xu, Q. (2017) Functional characterization of interferon regulatory factor 5 and its role in the innate antiviral immune response. Fish & shellfish immunology. 72:31-36
|
|
Altmann, S.M., Mellon, M.T., Johnson, M.C., Paw, B.H., Trede, N.S., Zon, L.I., and Kim, C.H. (2004) Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. Developmental and comparative immunology. 28(4):295-306
|
Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., Falco, A. (2020) Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports. 10:566
|
Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
|
Brudal, E., Ulanova, L.S., Lampe, E.O., Rishovd, A.L., Griffiths, G., Winther-Larsen, H.C. (2014) Establishment of Three Francisella Infections in Zebrafish Embryos at Different Temperatures. Infection and Immunity. 82(6):2180-94
|
|
|
Chen, H.Y., Liu, W., Wu, S.Y., Chiou, P.P., Li, Y.H., Chen, Y.C., Lin, G.H., Lu, M.W., Wu, J.L. (2015) RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish & shellfish immunology. 43(2):427-35
|
Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
|
Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P., Chang, M.X. (2015) MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and comparative immunology. 49:19-30
|
Cheng, C.C., Yang, W.Y., Hsiao, M.C., Lin, K.H., Lee, H.W., Yuh, C.H. (2020) Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis. Biomolecules. 10(6):
|
Chernyavskaya, Y., Mudbhary, R., Tokarz, D., Jacob, V., Gopinath, S., Zhang, C., Sun, X., Wang, S., Magnani, E., Madakashira, B.P., Yoder, J.A., Hoshida, Y., Sadler, K.C. (2017) Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development (Cambridge, England). 144(16):2925-2939
|
|
|
Contreras, M., Pacheco, I., Alberdi, P., Díaz-Sánchez, S., Artigas-Jerónimo, S., Mateos-Hernández, L., Villar, M., Cabezas-Cruz, A., de la Fuente, J. (2020) Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model. Frontiers in cellular and infection microbiology. 10:78
|
Cuvry, A., Gozalbo-Rovira, R., Strubbe, D., Neyts, J., de Witte, P., Rodríguez-Díaz, J., Rocha-Pereira, J. (2022) The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae. Microbiology spectrum. 10(6):e0315722
|
Danilova, N., Wilkes, M., Bibikova, E., Youn, M.Y., Sakamoto, K.M., Lin, S. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports. 8:5165
|
Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
|
Dong, X., Zhang, Z., Meng, S., Pan, C., Yang, M., Wu, X., Yang, L., Xu, H. (2018) Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. The Science of the total environment. 610-611:291-297
|
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
|
|
Gabor, K.A., Goody, M.F., Mowel, W.K., Breitbach, M.E., Gratacap, R.L., Witten, P.E., Kim, C.H. (2014) Influenza a virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Disease models & mechanisms. 7(11):1227-37
|
García-Valtanen, P., Martinez-Lopez, A., Ortega-Villaizan, M., Perez, L., Coll, J.M., and Estepa, A. (2014) In addition to its antiviral and immunomodulatory properties, the zebrafish Beta-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Research. 101:136-147
|
García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Ortega-Villaizán, M.D., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:121
|
Hamilton, N., Rutherford, H.A., Petts, J.J., Isles, H.M., Weber, T., Henneke, M., Gärtner, J., Dunning, M.J., Renshaw, S.A. (2020) The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. 68(7):1531-1545
|
|
Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84
|
|
Huang, C.J., Chou, C.M., Lien, H.W., Chu, C.Y., Ho, J.Y., Wu, Y., Cheng, C.H. (2017) IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Marine biotechnology (New York, N.Y.). 19(3):310-319
|
Huang, W., Zhao, X., Ji, N., Guo, J., Feng, J., Chen, K., Wu, Y., Wang, J., Feng, H., Zou, J. (2022) IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Journal of virology. 96(22):e0131422
|
Jiang, J., Gu, J., Zhan, A., Mao, M., Liu, Y., Wang, H., Mao, Y. (2022) Cloning, Exogenous Expression and Function Analysis of Interferon-γ from Gadus macrocephalus. Viruses. 14(10):
|
Kavaliauskis, A., Arnemo, M., Kim, S.H., Ulanova, L., Speth, M., Novoa, B., Dios, S., Evensen, Ø., Griffiths, G.W., Gjøen, T. (2015) Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 12(6):421-31
|
Kavaliauskis, A., Arnemo, M., Speth, M.T., Lagos, L., Rishovd, A.L., Estepa, A., Griffiths, G., Gjøen, T. (2016) Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Developmental and comparative immunology. 61:248-57
|
Laghi, V., Rezelj, V., Boucontet, L., Frétaud, M., Da Costa, B., Boudinot, P., Salinas, I., Lutfalla, G., Vignuzzi, M., Levraud, J.P. (2022) Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Frontiers in cellular and infection microbiology. 12:790851
|
Lagos, L., Tandberg, J.I., Repnik, U., Boysen, P., Ropstad, E., Varkey, D., Paulsen, I.T., Winther-Larsen, H.C. (2017) Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. Clinical and vaccine immunology : CVI. 24(5)
|
Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System. Journal of immunology (Baltimore, Md. : 1950). 178(7):4385-4394
|
Levraud, J.P., Jouneau, L., Briolat, V., Laghi, V., Boudinot, P. (2019) IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity. Journal of immunology (Baltimore, Md. : 1950). 203(12):3361-3373
|
Li, C., Zhong, S., Ni, S., Liu, Z., Zhang, S., Ji, G. (2021) Zebrafish Ism1 is a novel antiviral factor that positively regulates antiviral immune responses. Developmental and comparative immunology. 125:104210
|
Li, Z., Xu, X., Huang, L., Wu, J., Lu, Q., Xiang, Z., Liao, J., Weng, S., Yu, X., and He, J. (2010) Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & shellfish immunology. 29(3):399-406
|
Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422
|
Liu, J., Wei, T., Wu, X., Zhong, H., Qiu, W., Zheng, Y. (2019) Early exposure to environmental levels of sulfamethoxazole triggers immune and inflammatory response of healthy zebrafish larvae. The Science of the total environment. 703:134724
|
Liu, L., Song, D.W., Liu, G.L., Shan, L.P., Qiu, T.X., Chen, J. (2020) Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo. Zoological research. 41(4):395-409
|
Liu, W., Jin, Y., Zhang, W., Xiang, Y., Jia, P., Yi, M., Jia, K. (2020) MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination. Viruses. 12(3):
|
Ludwig, M., Palha, N., Torhy, C., Briolat, V., Colucci-Guyon, E., Brémont, M., Herbomel, P., Boudinot, P., and Levraud, J.P. (2011) Whole-Body Analysis of a Viral Infection: Vascular Endothelium is a Primary Target of Infectious Hematopoietic Necrosis Virus in Zebrafish Larvae. PLoS pathogens. 7(2):e1001269
|
Lutfalla, G., Roest Crollius, H., Stange-Thomann, N., Jaillon, O., Mogensen, K., and Monneron, D. (2003) Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 4(1):29
|
M, R., Medina-Gali, ., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M.M., Encinar, J.A., Novoa, B., Coll, J., Perez, L. (2018) Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & shellfish immunology. 82:514-521
|
Maarifi, G., Smith, N., Maillet, S., Moncorgé, O., Chamontin, C., Edouard, J., Sohm, F., Blanchet, F.P., Herbeuval, J.P., Lutfalla, G., Levraud, J.P., Arhel, N.J., Nisole, S. (2019) TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Science advances. 5:eaax3511
|
Morick, D., Faigenbaum, O., Smirnov, M., Fellig, Y., Inbal, A., Kotler, M. (2015) Mortality Caused by Bath Exposure of Zebrafish (Danio rerio) Larvae to Nervous Necrosis Virus Is Limited to the Fourth Day Postfertilization. Applied and environmental microbiology. 81(10):3280-7
|
|
|
|
|
|
Novoa, B., Pereiro, P., López-Muñoz, A., Varela, M., Forn-Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez-López, A., Medina-Gali, R.M., Collado, M., Coll, J., Estepa, A., Cayuela, M.L., Mulero, V., Figueras, A. (2019) Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 18(5):e13020
|
Novoa, B., Romero, A., Mulero, V., Rodriguez, I., Fernandez, I., and Figueras, A. (2006) Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 24(31-31):5806-5816
|
|
Pereiro, P., Forn-Cuní, G., Dios, S., Coll, J., Figueras, A., Novoa, B. (2017) Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Antiviral Research. 145:146-159
|
|
Rajshekar, S., Yao, J., Arnold, P.K., Payne, S.G., Zhang, Y., Bowman, T.V., Schmitz, R.J., Edwards, J.R., Goll, M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. eLIFE. 7:
|
Rakus, K., Mojzesz, M., Widziolek, M., Pooranachandran, N., Teitge, F., Surachetpong, W., Chadzinska, M., Steinhagen, D., Adamek, M. (2020) Antiviral response of adult zebrafish (Danio rerio) during tilapia lake virus (TiLV) infection. Fish & shellfish immunology. 101:1-8
|
|
Ruyra, A., Torrealba, D., Morera, D., Tort, L., MacKenzie, S., Roher, N. (2015) Zebrafish liver (ZFL) cells are able to mount an anti-viral response after stimulation with Poly (I:C). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 182:55-63
|
|
|
|
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
|
Sullivan, C., Jurcyzszak, D., Goody, M.F., Gabor, K.A., Longfellow, J.R., Millard, P.J., Kim, C.H. (2017) Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses. Journal of visualized experiments : JoVE. (119)
|
Thwaite, R., Ji, J., Torrealba, D., Coll, J., Sabés, M., Villaverde, A., Roher, N. (2018) Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics. Frontiers in immunology. 9:1652
|
Tian, J., Zhang, Y., Zhu, R., Wu, Y., Liu, X., Wang, X. (2020) Red elemental selenium (Se0 ) improves the immunoactivities of EPC cells, crucian carp and zebrafish against spring viremia of carp virus (SVCV). Journal of Fish Biology. 98(1):208-218
|
Tokarz, D.A., Heffelfinger, A.K., Jima, D.D., Gerlach, J., Shah, R.N., Rodriguez-Nunez, I., Kortum, A.N., Fletcher, A.A., Nordone, S.K., Law, J.M., Heber, S., Yoder, J.A. (2017) Disruption of Trim9 function abrogates macrophage motility in vivo. Journal of Leukocyte Biology. 102(6):1371-1380
|
Van Dycke, J., Ny, A., Conceição-Neto, N., Maes, J., Hosmillo, M., Cuvry, A., Goodfellow, I., Nogueira, T.C., Verbeken, E., Matthijnssens, J., de Witte, P., Neyts, J., Rocha-Pereira, J. (2019) A robust human norovirus replication model in zebrafish larvae. PLoS pathogens. 15:e1008009
|
Wang, W., Asim, M., Yi, L., Hegazy, A.M., Hu, X., Zhou, Y., Ai, T., Lin, L. (2015) Abortive Infection of Snakehead Fish Vesiculovirus in ZF4 Cells Was Associated with the RLRs Pathway Activation by Viral Replicative Intermediates. International Journal of Molecular Sciences. 16:6235-50
|
Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21
|
Widziolek, M., Janik, K., Mojzesz, M., Pooranachandran, N., Adamek, M., Pecio, A., Surachetpong, W., Levraud, J.P., Boudinot, P., Chadzinska, M., Rakus, K. (2020) Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection. Developmental and comparative immunology. 116:103936
|
Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
|
|
Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231
|
|
Xiong, R., Nie, L., Xiang, L.X., and Shao, J.Z. (2012) Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution. Journal of immunology (Baltimore, Md. : 1950). 188(6):2653-2668
|
Xu, H., Shao, X., Zhang, Z., Zou, Y., Wu, X., and Yang, L. (2013) Oxidative stress and immune related gene expression following exposure to di-n-butyl phthalate and diethyl phthalate in zebrafish embryos. Ecotoxicology and environmental safety. 93:39-44
|
|
Yoon, S., Alnabulsi, A., Wang, T.Y., Lee, P.T., Chen, T.Y., Bird, S., Zou, J., Secombes, C.J. (2016) Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Fish & shellfish immunology. 57:79-86
|
Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43
|
Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485
|
Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318
|
Zou, P.F., Chang, M.X., Li, Y., Xue, N.N., Li, J.H., Chen, S.N., Nie, P. (2016) NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS. Fish & shellfish immunology. 55:173-85
|
Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N., Nie, P. (2015) Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish & shellfish immunology. 43(1):13-24
|
Zou, P.F., Chang, M.X., Xue, N.N., Liu, X.Q., Li, J.H., Fu, J.P., Chen, S.N., and Nie, P. (2014) Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 141(2):192-202
|