ZFIN

ZFIN ID: ZDB-GENE-000511-2

ZFIN ID: ZDB-GENE-000511-2

CITATIONS (70 total)

Gene Name:	PYD and CARD domain containing
Gene Symbol:	pycard

Harapas, C.R., Robinson, K.S., Lay, K., Wong, J., Moreno Traspas, R., Nabavizadeh, N., Rass-Rothschild, A., Boisson, B., Drutman, S.B., Laohamonthonkul, P., Bonner, D., Xiong, J.R., Gorrell, M.D., Davidson, S., Yu, C.H., Fleming, M.D., Gudera, J., Stein, J., Ben-Harosh, M., Groopman, E., Shimamura, A., Tamary, H., Kayserili, H., Hatipoğlu, N., Casanova, J.L., Bernstein, J.A., Zhong, F.L., Masters, S.L., Reversade, B. (2022) DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Science immunology. 7:eabi4611

Lozano-Gil, J.M., Rodríguez-Ruiz, L., Tyrkalska, S.D., García-Moreno, D., Pérez-Oliva, A.B., Mulero, V. (2022) Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation. Developmental and comparative immunology. 132:104404

Niu, L., Luo, G., Liang, R., Qiu, C., Yang, J., Xie, L., Zhang, K., Tian, Y., Wang, D., Song, S., Takiff, H.E., Wong, K.W., Fan, X., Gao, Q., Yan, B. (2022) Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish. Frontiers in immunology. 13:893611

Shkarina, K., Hasel de Carvalho, E., Santos, J.C., Ramos, S., Leptin, M., Broz, P. (2022) Optogenetic activators of apoptosis, necroptosis, and pyroptosis. The Journal of cell biology. 221(6):

Tyrkalska, S.D., Martínez-López, A., Arroyo, A.B., Martínez-Morcillo, F.J., Candel, S., García-Moreno, D., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V. (2022) Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern. Science advances. 8:eabo0732

Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626

Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523

Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515

Matsui, H., Ito, J., Matsui, N., Uechi, T., Onodera, O., Kakita, A. (2021) Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nature communications. 12:3101

Molagoda, I.M.N., Athapaththu, A.M.G.K., Choi, Y.H., Park, C., Jin, C.Y., Kang, C.H., Lee, M.H., Kim, G.Y. (2021) Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants (Basel, Switzerland). 10(8):

Frame, J.M., Kubaczka, C., Long, T.L., Esain, V., Soto, R.A., Hachimi, M., Jing, R., Shwartz, A., Goessling, W., Daley, G.Q., North, T.E. (2020) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Developmental Cell. 55(2):133-149.e6

Mai, Y., Peng, S., Li, H., Gao, Y., Lai, Z. (2020) NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 240:108935

Pereiro, P., Figueras, A., Novoa, B. (2020) Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity. Vaccines. 8(2):

Wang, Z., Gu, Z., Hou, Q., Chen, W., Mu, D., Zhang, Y., Liu, Q., Liu, Z., Yang, D. (2020) Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo. Journal of immunology (Baltimore, Md. : 1950). 204(7):1929-1942

Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W., Wen, Z. (2020) Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. The Journal of biological chemistry. 295(26):8846-8856

Bruch-Bertani, J.P., Uribe-Cruz, C., Pasqualotto, A., Longo, L., Ayres, R., Bortolin Beskow, C., Luis Barth, A., Lima-Morales, D., Meurer, F., Tayguara, G., Guerreiro, S., da Silveira, T.R., Álvares-da-Silva, M.R., Dall'Alba, V. (2019) Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish. Journal of the American College of Nutrition. 39(2):163-170

Li, J.Y., Wang, Y.Y., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. The Journal of biological chemistry. 295(4):1120-1141

Matty, M.A., Knudsen, D.R., Walton, E.M., Beerman, R.W., Cronan, M.R., Pyle, C.J., Hernandez, R.E., Tobin, D.M. (2019) Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. eLIFE. 8:

Sepahi, A., Kraus, A., Casadei, E., Johnston, C.A., Galindo-Villegas, J., Kelly, C., García-Moreno, D., Muñoz, P., Mulero, V., Huertas, M., Salinas, I. (2019) Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 116(25):12428-12436

Tyrkalska, S.D., Pérez-Oliva, A.B., Rodríguez-Ruiz, L., Martínez-Morcillo, F.J., Alcaraz-Pérez, F., Martínez-Navarro, F.J., Lachaud, C., Ahmed, N., Schroeder, T., Pardo-Sánchez, I., Candel, S., López-Muñoz, A., Choudhuri, A., Rossmann, M.P., Zon, L.I., Cayuela, M.L., García-Moreno, D., Mulero, V. (2019) Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 51(1):50-63.e5

Valera-Pérez, A., Tyrkalska, S.D., Viana, C., Rojas-Fernández, A., Pelegrín, P., García-Moreno, D., Pérez-Oliva, A.B., Mulero, V. (2019) WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance. Developmental and comparative immunology. 100:103428

Wang, T., Yan, B., Lou, L., Lin, X., Yu, T., Wu, S., Lu, Q., Liu, W., Huang, Z., Zhang, M., Zhang, W., Wen, Z. (2019) Nlrc3-like is required for microglia maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 46(6):291-299

Arias-Jayo, N., Abecia, L., Alonso-Sáez, L., Ramirez-Garcia, A., Rodriguez, A., Pardo, M.A. (2018) High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Microbial ecology. 76(4):1089-1101

Huang, C., Niethammer, P. (2018) Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in Zebrafish. Immunity. 48:1006-1013.e6

Li, J.Y., Gao, K., Shao, T., Fan, D.D., Hu, C.B., Sun, C.C., Dong, W.R., Lin, A.F., Xiang, L.X., Shao, J.Z. (2018) Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 201(7):1946-1966

Li, Y., Huang, Y., Cao, X., Yin, X., Jin, X., Liu, S., Jiang, J., Jiang, W., Xiao, T.S., Zhou, R., Cai, G., Hu, B., Jin, T. (2018) Functional and Structural Characterization of Zebrafish ASC. The FEBS journal. 285(14):2691-2707

Uusi-Mäkelä, M.I.E., Barker, H.R., Bäuerlein, C.A., Häkkinen, T., Nykter, M., Rämet, M. (2018) Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio). PLoS One. 13:e0196238

Kuri, P., Schieber, N.L., Thumberger, T., Wittbrodt, J., Schwab, Y., Leptin, M. (2017) Dynamics of in vivo ASC speck formation. The Journal of cell biology. 216(9):2891-2909

Tyrkalska, S.D., Candel, S., Pérez-Oliva, A.B., Valera, A., Alcaraz-Pérez, F., García-Moreno, D., Cayuela, M.L., Mulero, V. (2017) Identification of an Evolutionarily Conserved Ankyrin Domain-Containing Protein, Caiap, Which Regulates Inflammasome-Dependent Resistance to Bacterial Infection. Frontiers in immunology. 8:1375

Tyrkalska, S.D., Candel, S., Angosto, D., Gómez-Abellán, V., Martín-Sánchez, F., García-Moreno, D., Zapata-Pérez, R., Sánchez-Ferrer, Á., Sepulcre, M.P., Pelegrín, P., Mulero, V. (2016) Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nature communications. 7:12077

Xie, J., Belosevic, M. (2016) Functional characterization of apoptosis-associated speck-like protein (ASC) of the goldfish (Carassius auratus L.). Developmental and comparative immunology. 65:201-210

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Progatzky, F., Sangha, N.J., Yoshida, N., McBrien, M., Cheung, J., Shia, A., Scott, J., Marchesi, J.R., Lamb, J.R., Bugeon, L., Dallman, M.J. (2014) Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nature communications. 5:5864

Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45

Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40

Jin, T., Huang, M., Smith, P., Jiang, J., and Xiao, T.S. (2013) Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(8):855-860

Shiau, C.E., Monk, K.R., Joo, W., and Talbot, W.S. (2013) An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development. Cell Reports. 5(5):1342-1352

Pradhan, A., Khalaf, H., Ochsner, S.A., Sreenivasan, R., Koskinen, J., Karlsson, M., Karlsson, J., McKenna, N.J., Orban, L., and Olsson, P.E. (2012) Activation of NF-kappaB prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. The Journal of biological chemistry. 287(45):37926-37938

Chang, M.X., Chen, W.Q., and Nie, P. (2010) Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Developmental and comparative immunology. 34(1):1-13

Sun, Y., Wang, J., Lao, H., Yin, Z., He, W., Weng, S., Yu, X., Chan, S., and He, J. (2008) Molecular cloning and expression analysis of the ASC gene from mandarin fish and its regulation of NF-kappaB activation. Developmental and comparative immunology. 32(4):391-399

Masumoto, J., Zhou, W., Chen, F.F., Su, F., Kuwada, J.Y., Hidaka, E., Katsuyama, T., Sagara, J., Taniguchi, S., Ngo-Hazelett, P., Postlethwait, J.H., Nuñez, G., and Inohara, N. (2003) Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal arch development. The Journal of biological chemistry. 278(6):4268-4276

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Martinon, F., Hofmann, K., and Tschopp, J. (2001) The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Current biology : CB. 11(4):R118-R120

Inohara, N. and Nuñez, G. (2000) Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell death and differentiation. 7(5):509-510

Additional Citations (26):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

Zebrafish Nomenclature Committee (2019) Nomenclature Data Curation (2019). Nomenclature Committee Submission.

Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.