Phenotype Summary

Phenotypes

Publication	Data		Phenotype
Saraswathy et al., 2022	Figure 1		convergent extension involved in gastrulation normal process quality, abnormal
Xie et al., 2020	Fig 6		pronephric duct e2f5 expression increased distribution, abnormal
Gou et al., 2018	Fig. 9		otic vesicle atoh1a expression increased amount, abnormal otic vesicle atoh1a expression increased distribution, abnormal otic vesicle atoh1a expression spatial pattern, abnormal otic vesicle neurog1 expression increased amount, abnormal otic vesicle neurog1 expression increased distribution, abnormal otic vesicle neurog1 expression spatial pattern, abnormal
Kawahara et al., 2018	Fig. S3		hypochord ly97.3 expression absent, abnormal
Kuwabara et al., 2018	Fig. 1		brain hk1 expression increased amount, abnormal brain ldha expression increased amount, abnormal brain pkma expression increased amount, abnormal brain slc2a3a expression increased amount, abnormal spinal cord hk1 expression increased amount, abnormal spinal cord ldha expression increased amount, abnormal spinal cord pkma expression increased amount, abnormal spinal cord slc2a3a expression increased amount, abnormal
	Fig. 2		whole organism elavl3 expression increased amount, abnormal whole organism hk1 expression increased amount, abnormal whole organism hk2 expression increased amount, abnormal whole organism ldha expression increased amount, abnormal whole organism pkma expression increased amount, abnormal whole organism slc2a3a expression increased amount, abnormal
	Fig. 3		brain hk1 expression decreased amount, abnormal brain hk2 expression increased amount, abnormal brain ldha expression decreased amount, abnormal brain pkma expression decreased amount, abnormal brain slc2a3a expression decreased amount, abnormal retina hk2 expression increased amount, abnormal retina slc2a1a expression decreased amount, abnormal
	Fig. 4		whole organism elavl3 expression decreased amount, abnormal whole organism hk2 expression increased amount, abnormal whole organism ldha expression decreased amount, abnormal whole organism pkma expression decreased amount, abnormal whole organism slc2a1a expression decreased amount, abnormal whole organism slc2a3a expression decreased amount, abnormal
Anuppalle et al., 2017	Fig. 5		hindbrain prune2 expression increased amount, abnormal spinal cord prune2 expression increased amount, abnormal telencephalon prune2 expression increased amount, abnormal
Gore et al., 2016	Fig. 1		ventral wall of dorsal aorta dnmt3bb.1 expression decreased amount, abnormal whole organism dnmt3bb.1 expression decreased amount, abnormal
Mahony et al., 2016	Fig. 1		neural crest tfec expression absent, abnormal ventral wall of dorsal aorta runx1 expression absent, abnormal
Shin et al., 2016	Fig. 7		dorsal aorta flt4 expression increased amount, abnormal intersegmental vessel flt4 expression decreased amount, abnormal intersegmental vessel decreased length, abnormal
Thambyrajah et al., 2016	Fig. 4		hematopoietic multipotent progenitor cell gfi1aa expression absent, abnormal inner ear gfi1aa expression increased amount, abnormal
Cheng et al., 2015	Fig. 2		nervous system dtx1 expression increased amount, abnormal whole organism dtx1 expression increased amount, abnormal
Ghaye et al., 2015	Fig. 5		nervous system ascl1b expression increased amount, abnormal nervous system nkx6.1 expression decreased amount, abnormal pancreas primordium ascl1b expression increased amount, abnormal pancreas primordium nkx6.1 expression absent, abnormal pancreas primordium nkx6.1 expression decreased amount, abnormal
Lin et al., 2015	Fig. 2		ventral wall of dorsal aorta hematopoietic multipotent progenitor cell myb expression absent, abnormal ventral wall of dorsal aorta hematopoietic multipotent progenitor cell absent, abnormal
	Fig. 4		ventral wall of dorsal aorta hematopoietic multipotent progenitor cell myb expression absent, abnormal ventral wall of dorsal aorta hematopoietic multipotent progenitor cell absent, abnormal
Rider et al., 2015	Fig. 5		anterior mesenteric artery ren expression absent, abnormal blood circulation arrested, abnormal brain hemorrhagic, abnormal caudal fin malformed, abnormal caudal fin unpigmented, abnormal embryonic structure ren expression absent, abnormal pericardium edematous, abnormal
Rodríguez-Fraticelli et al., 2015	Fig. 6		enterocyte differentiation decreased occurrence, abnormal intestinal epithelium endocytosis decreased occurrence, abnormal intestinal epithelium has fewer parts of type enterocyte, abnormal
Stooke-Vaughan et al., 2015	Fig. 5		otic vesicle has extra parts of type hair cell, abnormal otic vesicle has fewer parts of type auditory epithelial support cell, abnormal
Zhou et al., 2015	Fig. 2		pronephric tubule mcidas expression increased distribution, abnormal pronephric tubule has extra parts of type pronephric tubule multi-ciliated epithelial cell, abnormal pronephros multi-ciliated epithelial cell differentiation increased occurrence, abnormal
Imai et al., 2014	Fig. 7		neural retina development disrupted, abnormal
	Fig. 8		retinal ganglion cell axon guidance process quality, normal retinal ganglion cell axon increased accumulation retina ventral region, abnormal
Okigawa et al., 2014	Fig. 1		CiD increased amount, abnormal VeLD decreased amount, abnormal
Pascoal et al., 2013	Fig. 2		pectoral fin endoskeletal disc disorganized, abnormal pectoral fin fold morphology, abnormal
	Fig. 3		pectoral fin cartilage present, normal pectoral fin musculature present, normal
	Fig. 4		pectoral fin actin filament mislocalised, abnormal pectoral fin musculature contractile muscle fiber malformed, abnormal
	Fig. 5		pectoral fin myofibril disheveled, abnormal
	Fig. 7		pectoral fin myoblast decreased amount, abnormal
Obholzer et al., 2012	Fig. S7		inner ear morphology, abnormal
Porazzi et al., 2012	Fig. 1		thyroid gland development decreased process quality, abnormal thyroid primordium disorganized, abnormal thyroid primordium mislocalised, abnormal thyroid primordium physical object quality, abnormal
	Fig. 2		thyroid gland development decreased process quality, abnormal thyroid primordium increased volume, abnormal
	Fig. 3		pharyngeal vasculature separated from thyroid primordium, abnormal thyroid primordium mislocalised ventrally, abnormal
	Fig. 4		pharyngeal endoderm morphology, normal
	Fig. 5		apoptotic process occurrence, normal cell population proliferation occurrence, normal
	Fig. S1		thyroid gland development decreased process quality, abnormal thyroid primordium disorganized, abnormal thyroid primordium increased size, abnormal
Kapsimali et al., 2011	Fig. 6		pharyngeal arch 3 epithelium physical object quality, abnormal taste bud formation decreased process quality, abnormal taste bud physical quality, abnormal
Mizoguchi et al., 2011	Fig. 1		posterior lateral line ganglion neuron increased amount, abnormal
	Fig. 5		posterior lateral line ganglion neuron increased amount, abnormal posterior lateral line primordium cell decreased amount, abnormal
Herrgen et al., 2010	Fig. 2		somitogenesis delayed, abnormal
	Fig. 3		somite 2 increased length, abnormal somite 3 increased length, abnormal somite 4 increased length, abnormal somite 5 increased length, abnormal somitogenesis delayed, abnormal
	Fig. 4		somite increased length, abnormal somitogenesis delayed, abnormal
	Fig. 5		somitogenesis delayed, abnormal
	Fig. S2		axis elongation rate, normal embryo development rate, normal
Mahler et al., 2010	Fig. 7		caudal tuberculum morphology, abnormal
Yamaguchi et al., 2010	Fig. 5		eye proliferative region increased size, abnormal eye proliferative region mislocalised, abnormal retina disorganized, abnormal
Qiu et al., 2009	Fig. 1		hindbrain development disrupted, abnormal hindbrain epithelium disorganized, abnormal hindbrain neuroepithelial cell aggregated, abnormal neuroepithelial cell circular, abnormal rhombomere boundary formation disrupted, abnormal
	Fig. 2		hindbrain development disrupted, abnormal rhombomere boundary formation disrupted, abnormal
	Fig. 3		hindbrain development disrupted, abnormal rhombomere boundary formation disrupted, abnormal
So et al., 2009	Fig. 3		apoptotic process increased occurrence, abnormal trigeminal ganglion sensory neuron apoptotic, abnormal
Batista et al., 2008	Fig. 8		CiD increased amount, abnormal VeLD decreased amount, abnormal ventral spinal cord interneuron differentiation disrupted, abnormal
Cau et al., 2008	Fig. 3		epiphysis has extra parts of type neuron, abnormal
Pendeville et al., 2008	Fig. 6		vasculogenesis disrupted, abnormal
Aizawa et al., 2007	Fig. 4		determination of left/right symmetry disrupted, abnormal generation of neurons increased rate, abnormal habenula cellular quality, abnormal habenula development disrupted, abnormal habenula neuron morphology, abnormal
Hsiao et al., 2007	Fig. 2		ectoderm development disrupted, abnormal
	Fig. 3		epidermal cell fate specification disrupted, abnormal
	Fig. 5		ectoderm development disrupted, abnormal
Jänicke et al., 2007	Fig. 4		ionocyte progenitor cell foxi3a expression spatial pattern, abnormal ionocyte progenitor cell aggregated, abnormal ionocyte progenitor cell irregular spatial pattern, abnormal NaK ionocyte atp1b1b expression increased amount, abnormal NaK ionocyte increased amount, abnormal vH ionocyte atp6v1aa expression increased amount, abnormal vH ionocyte increased amount, abnormal
	Fig. 5		NaK ionocyte increased amount, abnormal vH ionocyte increased amount, abnormal
Schafer et al., 2007	Fig. 3		floor plate formation disrupted, abnormal lateral floor plate composition, abnormal ventral spinal cord interneuron specification disrupted, abnormal
Yeo et al., 2007	Fig. 7		spinal cord GABAergic neuron decreased amount, abnormal
Yeo et al., 2007	Fig. 5		central nervous system cellular quality, abnormal
Zhang et al., 2007	Fig. 1		post-vent region increased curvature, abnormal somite decreased amount, abnormal
	Fig. 2		post-vent region increased curvature, abnormal post-vent region melanocyte decreased amount, abnormal
	Table 1		post-vent region melanocyte decreased amount, abnormal somite decreased amount, abnormal
Phenotype Annotation (1994-2006)	Fig. for (ta52b)		brain quality, abnormal eye decreased size, abnormal gut quality, abnormal hindbrain quality, abnormal melanocyte irregular spatial pattern, abnormal nervous system quality, abnormal pigment cell quality, abnormal post-vent region quality, abnormal sensory system quality, abnormal somite quality, abnormal whole organism lethal (sensu genetics), abnormal
Kawamura et al., 2005	Fig. 2		somitogenesis disrupted, abnormal
Riley et al., 2004	Fig. 6		axon guidance disrupted, abnormal embryonic pattern specification disrupted, abnormal hindbrain commissure neuron absent, abnormal hindbrain disorganized, abnormal hindbrain radial glial cell disorganized, abnormal hindbrain radial glial cell increased amount, abnormal Mauthner neuron axon fasciculation, abnormal Mauthner neuron increased amount, abnormal primary neuron axon fasciculation, abnormal rhombomere morphology, abnormal rhombomere primary neuron increased amount, abnormal
Choi et al., 2003	Fig. 4		diencephalon celf2 expression increased amount, abnormal diencephalon celf2 expression increased distribution, abnormal hindbrain celf2 expression increased amount, abnormal hindbrain celf2 expression increased distribution, abnormal telencephalon celf2 expression increased amount, abnormal telencephalon celf2 expression increased distribution, abnormal
Heller et al., 2002	Fig. 4		auditory receptor cell fate specification process quality, abnormal hair cell anterior macula increased amount, abnormal hair cell posterior macula increased amount, abnormal
Lawson et al., 2001	Fig. 4		trunk curved, abnormal trunk pigmentation decreased process quality, abnormal
	Fig. 6		dorsal aorta disorganized, abnormal dorsal aorta fused with posterior cardinal vein, abnormal head hemorrhagic, abnormal intersegmental vessel disorganized, abnormal intersegmental vessel vascular sprouts mislocalised, abnormal posterior cardinal vein disorganized, abnormal
Gothilf et al., 1999	Fig. 4		pineal complex aanat2 expression increased distribution, abnormal
Halloran et al., 1999	Fig. 4		axon guidance process quality, abnormal diencephalon sema3d expression decreased amount, abnormal dorsoventral diencephalic tract axon guidance process quality, abnormal Rohon-Beard neuron axon guidance process quality, abnormal roof plate spinal cord region sema3d expression absent, abnormal
Riley et al., 1999	text only		otic vesicle has extra parts of type hair cell, abnormal
Haddon et al., 1998	Fig. 1		otic placode formation increased process quality, abnormal
	Fig. 4		neural plate primary neuron increased amount, abnormal
	Fig. 5		auditory epithelial support cell absent, abnormal hair cell anterior macula decreased amount, abnormal hair cell anterior macula increased amount, abnormal hair cell posterior macula decreased amount, abnormal hair cell posterior macula increased amount, abnormal lapillus decreased size, abnormal lapillus hypotrophic, abnormal otolith development arrested, abnormal sagitta decreased size, abnormal sagitta hypotrophic, abnormal
	Fig. 7		statoacoustic (VIII) ganglion hyperplastic, abnormal statoacoustic (VIII) ganglion increased size, abnormal
	text only		anterior crista absent, abnormal auditory epithelial support cell absent, abnormal cristae formation absent, abnormal hair cell anterior macula absent, abnormal hair cell posterior macula absent, abnormal inner ear hair cell absent, abnormal posterior crista absent, abnormal
Jiang et al., 1996	Fig. 1		hindbrain neural keel concave, abnormal rhombomere morphology, abnormal somite border morphology, abnormal trunk melanocyte absent, abnormal
	Fig. 2		anterior lateral line placode has extra parts of type sensory neuron, abnormal CoSA increased amount, abnormal epiphysis has extra parts of type neuron, abnormal hindbrain interneuron increased amount, abnormal Mauthner neuron increased amount, abnormal medial longitudinal fasciculus increased width, abnormal midbrain hindbrain boundary increased size, abnormal polster increased size, abnormal posterior lateral line placode has extra parts of type sensory neuron, abnormal pronephric duct increased size, abnormal rhombomere increased size, abnormal trigeminal ganglion has extra parts of type sensory neuron, abnormal trigeminal placode increased size, abnormal whole organism anterior-posterior axis has extra parts of type primary motor neuron, abnormal whole organism anterior-posterior axis has extra parts of type Rohon-Beard neuron, abnormal whole organism medial-lateral axis has extra parts of type Rohon-Beard neuron, abnormal
	Fig. 4		hindbrain dorsal region has fewer parts of type neuron, abnormal hindbrain has fewer parts of type radial glial cell, abnormal optic cup has fewer parts of type radial glial cell, abnormal pharyngeal endoderm morphology, normal trunk anterior region has fewer parts of type melanocyte, abnormal
	Fig. 5		somite decreased amount, abnormal somitogenesis delayed, abnormal somitomeric trunk muscle development process quality, normal
Kelsh et al., 1996	Table 2		integument has fewer parts of type pigment cell, abnormal post-vent region lacks all parts of type pigment cell, abnormal retinal pigmented epithelium morphology, normal
van Eeden et al., 1996	Table 1		somite morphology, abnormal somitogenesis disrupted, abnormal