- Title
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Exposure to perfluorooctanoic acid (PFOA) decreases neutrophil migration response to injury in zebrafish embryos
- Authors
- Pecquet, A.M., Maier, A., Kasper, S., Sumanas, S., Yadav, J.
- Source
- Full text @ BMC Res. Notes
Concentration–response graph showing acute toxicity and the 48-h LC50 of PFOA in zebrafish embryos. Concentration of PFOA (X-axis) plotted by the probability of mortality (Y-axis) in zebrafish embryos exposed for 48 h resulted in a derived LC50 of 300 mg/L using the ecotoxicity package in R. Each data point represents the average of the replicates from one experiment, and data are presented from five repeated experiments using a range of PFOA concentrations. Each concentration was tested a minimum of three times. Note that the high concentrations all had 100% mortality and those data points overlap |
Zebrafish embryos treated with PFOA showed a significant decrease in neutrophil accumulation following wounding. The zebrafish chemotaxis assay showed that PFOA treatment reduced the neutrophil number migrating to the wound site in 48-hpf zebrafish embryos. |