FIGURE SUMMARY
Title

Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway

Authors
Ai, N., Chong, C.M., Chen, W., Hu, Z., Su, H., Chen, G., Lei Wong, Q.W., Ge, W.
Source
Full text @ Oncotarget

Effects of Ponatinib on vascular development of zebrafish larvae. (A) Fluorescent images of ISV and SIV in the zebrafish embryos incubated with 0.1% DMSO (Ctrl: vehicle-control), VRI (5 μM), and Ponatinib (1, 3 and 10 μM) for 48 h. VRI was used as the positive control. Red arrow: normal ISV. (B) Number of normal ISV with full-length formation. (C) Quantification of SIV area as a percentage of the control group. The total SIV area was determined by using the NIH image J program. (D) Formation of selected ISV (NO. 4, 7, and 10). All values are presented as means ± SD (n = 12). *P < 0.05 vs. control group, and ***P < 0.005 vs. control group.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncotarget