FIGURE SUMMARY
Title

Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.

Authors
Kappel, S., Marques, I.J., Zoni, E., Stokłosa, P., Peinelt, C., Mercader, N., Kruithof-de Julio, M., Borgström, A.
Source
Full text @ Curr Mol Biol Rep

Activation of SOCE and TRPM4 as feedback mechanism for SOCE. Upon receptor stimulation, IP3 is produced and binds to the IP3 receptor. Subsequently, Ca2+ is released from intracellular Ca2+ stores. The decrease in Ca2+ in the ER results in the dissociation of Ca2+ from STIM1 proteins, which cluster and recruit and activate Orai1 channels in the plasma membrane that mediate SOCE. The increase in intracellular Ca2+ activates TRPM4. The Na+ influx via TRPM4 is a negative feedback mechanism for SOCE (please see text for details)

Evolution of cancer publications using the zebrafish model. The data were obtained from a PubMed search for “cancer + zebrafish”

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr Mol Biol Rep