El-Brolosy et al., 2017 - Genetic compensation: A phenomenon in search of mechanisms. PLoS Genetics   13:e1006780 Full text @ PLoS Genet.

Fig 1 Proposed models of transcriptional adaptation.

(A) DNA damage response can induce chromatin reorganization, increasing chromatin accessibility at the compensatory genes’ regulatory regions. (B) Mutations can lead to transcripts that are targeted for degradation through mRNA surveillance pathways. The resulting RNA fragments may trigger the compensatory response. As a secondary effect of the mutated gene’s mRNA degradation, RBPs or miRNAs normally acting on the mutated as well as the compensating genes’ mRNAs become more available to exert their stabilizing effects on the compensating genes’ mRNAs. Abbreviations: miRNAs, microRNAs; RBPs, RNA-binding proteins; TFs, transcription factors.

Acknowledgments:
ZFIN wishes to thank the journal PLoS Genetics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS Genet.