FIGURE SUMMARY
Title

Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair

Authors
Magadum, A., Ding, Y., He, L., Kim, T., Vasudevarao, M.D., Long, Q., Yang, K., Wickramasinghe, N., Renikunta, H.V., Dubois, N., Weidinger, G., Yang, Q., Engel, F.B.
Source
Full text @ Cell Res.
Fig. 4

PPARδ activity is required for adult cardiomyocyte cell cycle activity after injury in zebrafish. (A) Representative images of cryoinjured zebrafish hearts (7 dpi) treated with DMSO (control) or 5 μM PPARδ inhibitor (GSK3787), stained for PCNA (green) and the cardiomyocyte marker Mef2 (red). Nuclei were visualized using DAPI (blue). Dashed lines highlight the wound border zone used for quantification. Scale bar = 150 μm. (B) Quantitative analysis of PCNA-positive cardiomyocytes (DMSO: n = 9 hearts; GSK3787: n = 10 hearts; ***P < 0.001).
Fig. S6

PPARδ activity is required for adult cardiomyocyte proliferation in regenerating zebrafish hearts. (A) Representative images of cryoinjured myl7:GFPtwu34TG transgenic zebrafish showing GFP (green) in cardiomyocytes stained for H3P (red). Nuclei were visualized by staining DNA with DAPI (blue). (B) Quantitative analysis of H3P-positive cardiomyocytes (DMSO: n = 6 hearts; GSK3787: n = 7 hearts; *P < 0.05)
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Res.
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