Selected representative images of cyp1a/GPF expression in Tg(cyp1a:nls-egfp) transgenic zebrafish following chemical exposures. Examples of cyp1a/GFP expression patterns in the DMSO-exposed animals (A), liver (B), vasculature (C), yolk sac (D) and skin, neuromasts and liver (E) following exposure to indicated NPAHs. Expression patterns observed at 48 hpf (F) and 120 hpf (G), showing unique and overlapping cyp1a/GFP expression patterns for all compounds where expression in one or more tissues was observed. All results are summarized in Table 3.

Selected representative images of cyp1a/GPF expression in Tg(cyp1a:nls-egfp) transgenic zebrafish following chemical exposures and morpholino oligonucleotide injections. Examples of cyp1a/GFP expression patterns in the DMSO-exposed animals (A), liver (B), absence liver expression in AHR1A morphants (C), skin, neuromasts and liver (D), near-complete elimination of skin, neuromast, and vascular expression in AHR2 morphants (E), and complete skin, neuromast, and vasculature expression elimination (F) following co-injection of the AHR2 and AHR1B morpholinos, following exposure to indicated NPAHs.