Schwend et al., 2011 - Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in Zebrafish. Journal of Lipid Research   52(7):1328-44 Full text @ J. Lipid Res.

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Gene: npc1
Fish: WT
Anatomical Terms: nervous system, whole organism, whole organism anterior region, YSL
Stage Range: 2-cell to Days 7-13

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: epiboly involved in gastrulation with mouth forming second
Stage Range: Shield to Bud

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Gene: ta
Fish: WT, WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Anatomical Terms: forerunner cell group, mesoderm
Stage Range: 75%-epiboly to Bud
PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: epiboly involved in gastrulation with mouth forming second
Stage Range: 75%-epiboly to Bud

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish: WT + MO2-npc1
Knockdown Reagent: MO2-npc1
Observed In: epiboly involved in gastrulation with mouth forming second
Stage Range: Shield to Bud

Fig. 6 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: epiboly involved in gastrulation with mouth forming second
Stage: Bud

Fig. 7 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: actin cytoskeleton organization
Stage Range: 90%-epiboly to Bud

Fig. 9 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Genes: foxd3, pcdh8, ta
Fish: WT, WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Anatomical Terms: notochord, segmental plate, tail bud, whole organism anterior region
Stage: 5-9 somites
PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: cell death, lateral mesoderm, notochord, segmental plate, whole organism
Stage Range: 5-9 somites to 26+ somites

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:
Fish: WT + MO1-npc1
Knockdown Reagent: MO1-npc1
Observed In: whole organism
Stage: Long-pec
Full text @ J. Lipid Res.